Anticoagulants & Supplements Flashcards
Unfractionated Heprin
Heparin Anticoagulant Blood thinner Inactivation of thrombin & factor Xa Active bleeding, short half life, unpredictability Regular aPTT testing Antidote is protamine sulfate
Enoxaparin
Lovenox Anticoagulant - low molecular weight Blood thinner Inactivates factor Xa Active bleeding, no protein binding, renal dysfunction Monitor renal function and platelets
Warfarin
Coumadin
Anticoagulant - Vitamin K antagonist
Blood thinner
Inhibits synthesis of Vitamin K dependent clotting factors (II, VII, IX, X & Thrombin)
Bleeding, multiple drug interactions, constant monitoring of prothrombin and INR
Bleeding preparations before surgeries, watch diet and vitamin K intake
Dabigatran
Pradaxa
Anticoagulant - Direct Factor Xa inhibitor
Blood thinner
Direct thrombin inhibitor
Bleeding, GI effects, dark stools
Bleeding, drug interactions, antidote is idarucizumab
Rivaroxabin
Xarelto
Anticoagulant - Direct Factor Xa Inhibitor
Blood thinner
Factor Xa inhibitor
Bleeding
NO ANTIDOTE, less drug interactions, no labs to monitor
Ferrous Sulfate
Iron
Nutritional supplement
Iron deficiency anemia
GI disturbances, nausea, constipation, change in stool color
Can be toxic at high levels, reduced absorption with antacids, interacts with vitamin c
Iron Dextran
Iron Dextran
Parenteral Iron preparation
Iron deficiency anemia
Anaphylaxis, hypotension, circulatory failure, cardiac arrest
Start with test doses of 25mg over 5 minutes
Cyanocobalamin
Vitamin B12
Nutritional deficiency
Hypokalemia
Routinely check levels, never give as IV
Folic Acid
Nutritional supplement
Nutritional deficiency
Routinely check levels
Erythropoietin
Procrit
Erythropoietic growth factor
Stimulate red blood cell formation
Need to have enough iron, folic acid and B12