Unfractionated heparin - binds to antithrombin (AT) - inactivated thrombin - binds to clotting factors XII, XI, X and IX - inactivation of these factors = decrease in platelet aggregation and clot formation Low molecular weight heparin (LMWH) - longer duration of action and better dose-response relationship - molecular is more uniform and allows for more specific binding to receptor sites = fewer side effects

Anticoagulant Drugs Flashcards by Joyce Lau

Heparin

Unfractionated heparin
binds to antithrombin (AT)
inactivated thrombin
binds to clotting factors XII, XI, X and IX
inactivation of these factors = decrease in platelet aggregation and clot formation
Low molecular weight heparin (LMWH)
longer duration of action and better dose-response relationship
molecular is more uniform and allows for more specific binding to receptor sites = fewer side effects

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Anticoagulant Drugs Flashcards

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