Anticholinesterases

Question 1

Edrophonium

Answer 1

• edrophonium inhibits acetylcholinesterase at anionic sites w/ electrostatic bonding, esteratic sites with H-bonding (no chemical bond)
• fast onset, short-lived
• muscarinic side effects are less (1/2 atropine is needed to prevent bradycardia as is needed for neostigmine or pyridostigmine)-0.5-1 mg/kg

Question 2

neostigmine

Answer 2

• transfers carbamatic group to esteratic site

- 0.06-0.07 mg/kg

Question 3

pyridostigmine

Answer 3

-requires longer to act, longer duration of action

Question 4

physostigmine

Answer 4

• rx central anticholinergic syndrome

- tertiary amine (not quarternary)