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Big Blue Topics > Anti-platelet drugs > Flashcards

Anti-platelet drugs Flashcards

1
Q

Aspirin

A
  • irreversible nonselective COX-1 inhibitor

- COX1 catalyzes arachidonic acid–>prostaglandins–>plt aggregation

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2
Q

Glycoprotein IIb/IIIa receptors

A
  • allow fibrinogen to form a bridge between platelets, triggering platelet aggregation
  • GPIIb/IIIa inhibitors bind to the IIb/IIIa receptor, inhibiting aggregation
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3
Q

IV GPIIb/IIIa inhibitors

A

-abciximab
eptifibatide
tirofiban

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4
Q

oral GPIIb/IIIa inhibitors

A

ticlopidine
plavix (produces 40-60% inhibition of plts in 3-5 days)
-irreviersible inhibition of ADP on the P2Y12 portion of glycoprotein IIb/IIIa receptor

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Big Blue Topics (25 decks)

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