Antibodies and Antigens

Question 1

Antibodies are composed of

Answer 1

four poly peptide chains

Question 2

what are the two chains that make up the four peptides

Answer 2

two heavy and two light chains

Question 3

what shape is an antibody

Answer 3

-y-shaped

Question 4

what is in the y-shaped region

Answer 4

• bilateral symmetry
• two N-terminals
• C-terminal

Question 5

the N-terminal is
the C-terminal is

Answer 5

antigen binding sites
Constant region

Question 6

what is an antigen

Answer 6

molecule of microbe that interacte with the antigen binding site

Question 7

what are the 5 constant regions of

Answer 7

IgG, IgM, IgD, IgA, IgE

Question 8

what is the regions defined by

Answer 8

heavy chain constant region

Question 9

what do the constant region mediate

Answer 9

antibody effector functions

Question 10

IgM,IgG,IgA cause

Answer 10

an activation of complement

Question 11

IgG and IgE bind to

Answer 11

Fc receptors

Question 12

IgA can

Answer 12

transport to special sites like the mucosal surface

Question 13

what is the first antibody produced during immune response

Answer 13

Igm

Question 14

IgA prevents

Answer 14

attachment of bacteria and viruses to mucosal membrane, picks up secretory components from epithelial cells which protects Fc portion from luminal protease

Question 15

IgD is expressed

Answer 15

on surface of mature, naive B cells

Question 16

IgE

Answer 16

binds mast cells and basophils when exposed to allergens and contributes to immunity to parasites by activating Eosinphils

Question 17

which constant region can cross the placenta

Answer 17

IgG and provides the fetus with immunity

Question 18

Circulating IgM antibodies are

Answer 18

pentamers with 10 antigen binding sites

Question 19

Circulating IgA antibodies are

Answer 19

dimers and has 4 antigen binding sites

Question 20

the varients of IgG are encoded by

Answer 20

4 related gene segments

Question 21

Fab stands for and what does it determine

Answer 21

fragment antigen binding
determines idiotype

Question 22

how can fab be used clinically

Answer 22

protease cleavage can seperate antigen binding (Fab) from antibody effector function (Fc)

Question 23

what is the epitope

Answer 23

precise region of an antigen molecule that interacts with the antigen binding site

Question 24

one antigen can have

Answer 24

multiple different epitopes

Question 25

what are the two epitope types

Answer 25

linear (continuous)
discontinuous

Question 26

linear epitope is composed

Answer 26

of adjacent building blocks of antigen
(adjacent amino acid)

Question 27

discontinuous epitope is composes of

Answer 27

scattered building blocks brought closer by protein folding