Antibiotics - RNAp disruptors Flashcards
1
Q
What is the RNA disrupting agent for antibiotics?
A
Rifampin.
2
Q
What is rifampin good for?
A
Semi-dormant and active TB infections.
3
Q
True or false?
The red/orange urine of rifampin is a sign of overdosage.
A
False, it just gets excreted through bodily fluids, like sweat, tears, anemid urine.
4
Q
How long should rifampin be given for TB patients?
A
6-9 months.
5
Q
What are some of the side effect of rifampin?
A
Rapid resistance, hepatotoxicity, and Cyp450 interactions.
6
Q
What are some drugs who interact negatively with rifampin?
A
Warfarin, cyclosporins, glucocorticoids, OCPs, HIV treatments, digitoxin, methadone, anti-arrhythmics.
7
Q
What drug would you give to those with HIV and TB infections?
A
Rifabutin.
8
Q
What drug would you give to those with HIV and TB infections?
A
Rifabutin.
