Antibiotics - DNA gyrase acting

Question 1

What is the MoA for DNA gyrase acting antibiotics?

Answer 1

They cause the DNA gyrase to be unable to religate the nicks in DNA.

Question 2

What are the first gen fluoroquinolones?

Answer 2

Ciprofloxacin.

Question 3

What are the second gen fluoroquinolones?

Answer 3

Levofloxacin, gemifloxacin, and moxifloxacin.

Question 4

What does fluoroquinolone target in gram negative bacteria?

Answer 4

DNA gyrase.

Question 5

What does fluoroquinolone target in gram positive bacteria?

Answer 5

Topoisomerase IV.

Question 6

Are fluoroquinolones safe for prefnant mothers?

Answer 6

They shouldn’t be used unless there is no choice.

Question 7

Are fluoroquinolones safe for children?

Answer 7

It is not recommended due to risk of musculoskeletal damage.

Question 8

What are some nervous-related fluoroquinolone contraindiciations?

Answer 8

CNS lesions/inflammation and epilepsy.

Question 9

Should lactating mothers be given fluoroquinolones?

Answer 9

No, lactating mothers should not be given fluoroquinolones since it can affect their babies.