Antibiotics - folic acid pathway acting Flashcards
1
Q
Are folic acid pathway disruptors bacteriocidal or bacteriostatic?
A
Bacteriostatic.
2
Q
What are the 2 drugs commonly used in this pathway disruption?
A
Trimethoprim - sulfamethoxazole (TMP-SMX).
3
Q
What is the pathway for DNA and RNA synthesis using PABA?
A
Para-amino benzoic acid turns into dihydrofolic acid turns into dihydropteroic acid turns into tetrahydrofolic acid.
4
Q
True or false?
Sulfomethaxazole inhibits the formation of DHF acid.
A
True.
5
Q
Which step does trimethoprim inhibit?
A
The transformation of dihydropteric acid into tetrahydrofolic acid.
