ANTIBIOTICS: penicillins, cephalosporins, aminoclycosides, quinolones Flashcards
you can give penicillins on an empty stomach except
amoxicillin
this is not absorbed well orally
penicillin G
** these are inactivated by organic debris
aminoglycosides
penicillin-resistant bacteria secrete this
- what does it do?
- what other drugs can be affected by this?
beta lactamase enzyme
- disrupts the structure of penicillin molecule
- cephalosporins
keep an eye on withdrawal times with this medicine
penicillins - a lot of people are allergic
this cephalosporin is a 2 week injectable
Convenia (cefovecin)
this cephalosporin is not effective against pseudomonas
Convenia (cefovecin)
** these may cause crystal formation in the urine
quinolones
this cephalosporin is used for UTIs in cats and skin issues in dogs and cats
Convenia (cefovecin)
this cephalosporin used for skin infections is administered SID, which is why it’s sometimes the preferred one
Cefpodoxime (Simplicef)
1st generation cephalosporins are effective against
G+
2nd generation cephalosporins are effective against
G+ and some G-
these are not usually used in food animals because they have long Ass withdrawal times
aminoglycosides
if you’re allergic to penicillins, you’re probably also allergic to these:
cephalosporins
** these are hydrophillic at physiologic pH
aminoglycosides
** these are not well absorbed by the GI tract or uterus
aminoglycosides
** with these, use caution in animals with renal disease and poor renal perfusion
aminoglycosides
** these are potentially toxic to kidneys if overdosed
cephalosporins
** these 2 can cause superinfection in guinea pigs, hamsters, and rabbits (kills G+ bacteria in intestine and leaves G-)
- penicillins
- lincosamides
** some of these should not be mixed with penicillin in the same syringe
aminoglycosides
these are the newest antibiotic group
quinolones
these are reserved for treatment of more serious infections
quinolones
** with these, GI absorption is poor in mature ruminants
quinolones
** these accumulate in the inner ear (cause hearing loss) and kidney (causing toxicity)
aminoglycosides
** these may cause damage to articular cartilage of growing dogs and horses (although they treat parvo)
quinolones
these are not recommended for pregnant animals
quinolones