Antibiotics and PHARMACOLOGY Flashcards
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What is prophylaxis
use of antibiotics to prevent the development of an infection
what is a sterile part of the body
blood
What do protein synthesis inhibitors do to anti inflammatory cells
they inhibit protein synthesis in human cells and mainly the most active cells and during an infection the is the inflammatory cells
what are the two different types of antibiotics in terms of administering
Time dependent - keeping it high in the system eg 4 times a day
Dose dependent - hitting hard eg 250ml
what do bacteria for for resistance
biofilms
What do biofilms do
complex three-dimensional communities of microorganisms embedded in a matrix and they transmit mutated DNA and are hard to kill
what do biofilms like to attach to and why
device related infections ( artificial bits)
They are stable environments with no immune as they are normally plastic or metal and and it don’t shed because it are plastic English innit fam
what are incubators for resistance
biofilms
what does change the lines mean and why is it bad if you don’t
lines eg things going into bodies and they attract bio films
What does MDR mean (multi drug-resistant)
What does XDR mean (extensively drug resistant )
What does PDR mean (pandrug-resistant)
MDR - 1 or more drugs in 2 CLASSES
XDR - 3 or more CLASSES
PDR - ALL DRUGS AND ALL CLASSES RIP
What is the difference of Pharmacokinetics and Pharmacodynamics
Pharmacokinetics - what your body does to the drug
Pharmacodynamics - what the drug does to your body
what happens to the gastric acid secretion and SA in age
reduction in gastric acid secretion and GI tract SA is less
What happens to the body distribution in age
Muscle mass decrease
Total body water decrease
Body Fat Increase
what is firs pass metabolism
how much actually makes it past the liver
what happens to the renal function as you age and what does this mean
reduces 1ml/min/year
reduced clearance of drugs
