Antibiotics

Question 1

Fluorchinolone

Answer 1

Antibiotics: Chinolone = Fluorchinolone

• Beispiel Ciprofloxacin
• MOA: Inhibition of Gyrase and Topoisomerase IV: prevents bacterial DNA from unwinding & duplicating
• can induce QT-prolongation
  (especially: Moxifloxacin, kaum: Levofloxacin)

Question 2

Ciprofloxacin

Answer 2

Chinolone Antibiotic

• MOA: Inhibition of Gyrase and Topoisomerase IV: prevents bacterial DNA from unwinding & duplicating
• can induce QT-prolongation
  (especially: Moxifloxacin, kaum: Levofloxacin)

Question 3

Moxifloxacin

Answer 3

Chinolone Antibiotic

• MOA: Inhibition of Gyrase and Topoisomerase IV: prevents bacterial DNA from unwinding & duplicating
• can induce QT-prolongation
  (especially: Moxifloxacin, kaum: Levofloxacin)

Question 4

Macrolide

Answer 4

Antibiotic
- Beispiel: Erythromycin, Clarithromycin
- MOA:  binding to 23S rRNA in 50S subunit of bacterial ribosome → inhibition of bacterial translation
- can induce QT-prolongation
Prevention: 
\+ EKG prior to medication
\+ avoidance of K+/Mg2+ deficit (check + sup)
\+ lowest effective dose
\+ checking co-medication

Question 5

Penicillin

Answer 5

Antibiotic (ß-lactam-A.)
- MOA: inhibition of bacterial transpeptidase that catalyzes cross-linking of bacterial cell walls → death of bacterial cell

Question 6

Cephalosporine

Answer 6

Antibiotic (ß-lactam-A.)
- MOA: inhibition of bacterial transpeptidase that catalyzes cross-linking of bacterial cell walls → death of bacterial cell