Antibiotics

Question 1

What is the spectrum of activity of Piperacillin - Tazobactam?

Answer 1

Covers G(+)s, G(-)s, and Anaerobes, no major “holes in coverage”

Question 2

What is the coverage of 1st gen Cephs?

Answer 2

Staphylococcus, Streptococcus (G+ organisms) Does NOT cover enterococcus

Question 3

What is the coverage of 3nd gen Cephs?

Answer 3

Broader coverage above and below the diaphragm, more G(-) coverage

Question 4

What is the coverage of 4th gen Cephs?

Answer 4

Broadest Ceph coverage, both G(+) and G(-)

Question 5

What is the coverage of Ceftriaxone?

Answer 5

Covers most G(+) and G(-), does not cover Enterococcus or anaerobes

Question 6

What is the coverage of Cefepime?

Answer 6

Covers most (G+) and G(-) NOT enterococcus and not anaerobes

Question 7

What is the easiest way to think about ceftaroline?

Answer 7

It’s like a Cephtriaxone w/ MRSA coverage

Question 8

What is the coverage of Aztreonam?

Answer 8

Only G(-) organisms

Question 9

Which Carbapenem DOES NOT cover Pseudomonas?

Answer 9

Ertapenem

Question 10

What is the coverage of Carbepenems?

Answer 10

Everything except the most resistant organisms, those with carbipenemase enzyme

Question 11

What is the coverage of Vancomycin?

Answer 11

Covers G(+) organisms only, DOES NOT cover VRE or VISA/VRSA

Question 12

Which ABX can be used to treat MRSA or VRE?

Answer 12

Daptomycin

Question 13

What is the coverage of daptomycin?

Answer 13

G(+) organisms only, includes those resistant to Vancomycin

Question 14

What is the coverage of linezolid?

Answer 14

Covers G(+) organisms, including those resistant to vancomycin

Question 15

What is the coverage for tigecycline?

Answer 15

Most G(+) organisms, including resistant ones, most (G-) ones NOT PSEUDOMONAS, most anaerobes

Question 16

What is the main use of cefotetan?

Answer 16

Surgical prophylaxis (It has some anaerobic coverage)

Question 17

Which two cephs have anti-Pseudomonal coverage?

Answer 17

Ceftazidime and Cefepime

Question 18

Which are the best two oral Cephs?

Answer 18

Cefpodoxime and Cefdinir

Question 19

What is the important side effect of Cefdinir?

Answer 19

It binds to iron in the GI track and can turn the stool red.

Question 20

What is the drug of choice in treating MRSA meningitis?

Answer 20

Nafcillin

Question 21

Which Ceph is the only one not adjusted in renal failure?

Answer 21

Cephtriaxone

Question 22

Which FQ is the best for treating G(-) infections?

Answer 22

Cipro

Question 23

Which FQ is the best for treating G(+) infections

Answer 23

Avelox (Moxifloxicin)

Question 24

How does food intake affect FQ kinetics?

Answer 24

Changes absorption rate, but not Cmax

Question 25

Which FQ is used to treat UTI

Answer 25

Cipro

Question 26

Which FQs are “respiratory FQs”

Answer 26

Moxifloxicin and Levofloxacin

Question 27

What is the Pediatric dose of Amoxicillin?

Answer 27

25-50 mg/kg TID

Question 28

What is the coverage of Amoxicillin

Answer 28

G(+)s like Streptococcus, S. pneumoniae, S. milleri

Question 29

What is the Pediatric dose of Amox / Clav?

Answer 29

90 mg/kg/day divided BID (For OAM)

Question 30

What is the Adult dose of Amox / Clav?

Answer 30

875/125 mg bid

Question 31

How does Clavulanate change the spectrum of activity for Amoxicillin?

Answer 31

Greatly increased G(-) and Anaerobic activity, now covers G(-) bugs like E. coli, H flu,

Question 32

What is the usual Adult dose of Amoxicillin?

Answer 32

250-1000 mg po tid