Antibiotics Flashcards
Community/hospital-acquired septicaemia (unknown source) - penicillin allergy
Ciprofloxacin 400mg IV bd + Teicoplanin 400mg IV bd (6mg/kg if >85kg) for 3 doses, then 400mg IV od (6mg/kg if >85kg)
Community-acquired septicaemia (unknown source) - 1st line for non-penicillin allergic
Cefuroxime 1.5g IV tds
Community/hospital-acquired septicaemia (unknown source) + hypotension
+ Gentamycin 7mg/kg IV stat
Community/hospital-acquired septicaemia (unknown source) - anaerobe suspected e.g. bowel-derived flora
+ Metronidazole 500mg IV tds
Hospital-acquired septicaemia (unknown source) - 1st line for non-penicillin allergic
Piperacillin/tazobactam 4.5g IV tds
Neutropenic sepsis (all haematology except myeloma, all oncology except high risk neuroblastoma/sarcoma) - 1st line for non-penicillin allergic
Piperacillin/tazobactam 4.5g IV tds + Gentamycin 7mg/kg IV od
Avoid Gentamycin if creatinine clearance <70ml/min)
Stop gentamycin after 1 dose if cultures negative
Neutropenic sepsis (all haematology except myeloma, all oncology except high risk neuroblastoma/sarcoma) + endoprosthesis in situ/tunnel infection/rigors with central line access/suspicion of line colonisation
+ Teicoplanin 400mg IV bd (6mg/kg if >85kg) for 3 doses, then 400mg IV od (6mg/kg if >85kg)
Mild-moderate CAP (CURB-65 0-2) - 1st line for non-penicillin allergic
Amoxicillin 500mg-1g IV tds +/- Clarithromycin 500mg IV bd
Switch to oral when appropriate
Total duration 5 days
Mild-moderate CAP (CURB-65 0-2) - penicillin allergy
Clarithromycin 500mg IV bd
Switch to oral when appropriate
Total duration 5 days
Severe CAP (CURB-65 3+ or clinical judgement) - 1st line for non-penicillin allergic
Co-amoxyclav 1.2g IV tds + Clarithromycin 500mg IV bd
Switch to oral when appropriate
Total duration 7 days
Severe CAP (CURB-65 3+ or clinical judgement) - Non-severe penicillin allergic (e.g. delayed rash)
Cefuroxime 1.5g IV tds + Clarithromycin 500mg IV bd
Switch to oral when appropriate
Total duration 7 days
Severe CAP (CURB-65 3+ or clinical judgement) - Severe penicillin allergic (e.g. anaphylaxis, bronchospasm, urticaria)
Teicoplanin 400mg IV bd (6mg/kg if >85kg) for 3 doses, then 400mg IV od (6mg/kg if >85kg) + Clarithromycin 500mg IV bd
Switch to oral when appropriate
Total duration 7 days
Simple HAP (early admission, no ITU) - 1st line for non-penicillin allergic
Cefuroxime 1.5g IV tds -or- Co-amoxyclav 1.2g IV tds
Switch to oral when appropriate
Total duration 5 days
Simple HAP (early admission, no ITU) - penicillin allergy
Clarithromycin 500mg IV bd
Switch to oral when appropriate
Total duration 5 days
Aspiration pneumonia - 1st line for non-penicillin allergic
Co-amoxyclav 1.2g IV tds -or- 625mg PO tds
Review diagnosis after 3 days
Total duration 5 days
Aspiration pneumonia - penicillin allergy
Clindamycin 300mg IV/PO qds
Review diagnosis after 3 days
Total duration 5 days
Infective exacerbation of COPD (no consolidation on CXR) - 1st line for non-penicillin allergic
Amoxicillin 500mg PO tds
Total duration 5 days
Infective exacerbation of COPD (no consolidation on CXR) - penicillin allergy
Doxycycline 200mg PO od
Total duration 5 days
Uncomplicated community-acquired lower UTI - 1st line
Trimethoprim 200mg PO bd
F: 3 days
M: 7 days
Uncomplicated community-acquired lower UTI - alternative unless creatinine clearance <60ml/min
Nitrofurantoin 50mg PO qds
F: 3 days
M: 7 days
Uncomplicated community-acquired lower UTI - pregnant
Cefadroxil 500mg PO bd
7 days
Uncomplicated hospital-acquired lower UTI - 1st line
Trimethoprim 200mg PO bd
7 days
Uncomplicated hospital-acquired lower UTI - alternative unless creatinine clearance <60ml/min
Nitrofurantoin 50mg PO qds
7 days
Acute pyelonephritis - 1st line for non-penicillin allergic
Cefuroxime 750mg-1.5g IV tds for 48h Then Oral therapy per sensitivities -or- If no sensitivities, Ciprofloxacin 500mg PO bd Total duration 7 days if Ciprofloxacin 10 days for all other antibiotics
