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Y1 Drugs + bugs > Antibiotics > Flashcards

Antibiotics Flashcards

1
Q

Target cell wall

A

penicillins
cephalosporins
glycopeptides

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2
Q

glycopeptide mechanism of action

A

target cell wall side chains

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3
Q

what gram stain of bacteria do glycopeptides work on?

A

gram pos

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4
Q

penicillins mechanism of action

A

B-lactam ring
binds to PBP
prevents formation of peptidoglycan layers

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5
Q

gram +/- penicillin?

A

amox

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6
Q

what make up co-amoxiclav

A

amoxicillin
cluvulanic acid

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7
Q

beta-lactamase resistance?

A

co-amoxiclav
tazobactam

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8
Q

gram - coliform?

A

temocilin

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9
Q

staph and strep only?

A

fluclox

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10
Q

cephalosporin mechanism of action

A

Beta-lactam ring

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11
Q

ceftriaxone?

A

cephalosporin

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12
Q

vancomycin?

A

glycopeptide

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13
Q

teicoplanin?

A

glycopeptide

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14
Q

contraindiaction of glycopeptide?

A

kidney damage

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15
Q

target prokaryotic nucleic acid

A

fluroquinolones
trimethoprim
metronidazole

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16
Q

mechanism of action for quinolones

A

inhibit DNA synthesis
prevent DNA supercoiling

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17
Q

cover of quinolones?

A

gram -
few +

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18
Q

ciprofloxacin?

A

fluroquinolones

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19
Q

causes tendonitis?

A

fluroquinolones

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20
Q

inhibits folic acid synthesis?

A

trimethoprim

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21
Q

used to treat UTI

A

trimethoprim

22
Q

metronidazole mechanism of action?

A

inhibits prokaryotic nucleic acid

23
Q

anaerobic cover?

A

metronidazole

24
Q

protazoa cover?

A

metronidazole

25
Q

protein synthesis inhibitors?

A

teracyclines
macrolides
aminoglycosides

26
Q

bind to 30s and stops protein chain elongation

A

tetracyclines

27
Q

deoxycycline?

A

tetracycline

28
Q

minocycline?

A

tetracycline

29
Q

restricted use in infants?

A

tetracyclines

30
Q

binds to 50s subunit
interfere with protein synthesis

A

macrolides

31
Q

gram - macrolides

A

erythromycin
clarithromycin

32
Q

gram + macrolide?

A

azythromycin

33
Q

which macrolide is safe in pregnancy?

A

erythromycin

34
Q

binds to aminoacyl site of 16s within 30s
causes misread of genetic code

A

aminoglycosides

35
Q

gentamicin?

A

aminoglycoside

36
Q

gram - coliforms?

A

gentamicin

37
Q

is gent cidal or static?

A

bactericidal

38
Q

how is gent administered?

A

IV

39
Q

side effects of gent?

A

nephrotoxic
CN8 damage

40
Q

Abe causing aplastic anemia

A

chloramphenicol

41
Q

tendon rupture

A

ciprofloxacin

42
Q

treat typhoid fever

A

chloramphenicol

43
Q

mechanism of action for chloramphenicol

A

bind to 50s subunit
inhibit peptide transferase

44
Q

clindamycin mechanism

A

inhibits protein synthesis
bind to 50s ribosome

45
Q

inhibit DNA gyrase

A

quinolones

46
Q

inhibit folate synthesis

A

trimethoprim
sulphonamide

47
Q

causing photosensitive rash

A

tetracyclines

48
Q

dihydrofolate reductase inhibitor

A

trimethoprim

49
Q

amantadine

A

antiviral
inhibit M2 uncoating

50
Q

sulphonamide

A

inhibits folic acid synthesis

Y1 Drugs + bugs (8 decks)

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