Antibiotic Prophylaxis

Question 1

Inhibit DNA gyrase and Topoisomerase IV

Answer 1

Quinolones

Question 2

Target of quinolones in gram negative bacteria.

Answer 2

DNA gyrase

Question 3

Target of quinolones in gram positive bacteria.

Answer 3

Topoisomerase IV

Question 4

First generation Quinolone against gram negatives like pseudomonas and ANTHRAX

Answer 4

Ciprofloxacin

Question 5

Second generation quinolonoes are AKA:

Answer 5

Respiratory fluroquinolones

Question 6

Levofloxaxcin
Moxifloxacin
Gemifloxacin
Gatifloxacin

Answer 6

Second Generation Quinolones

Question 7

Secondary Quinolone contraindicated in diabetics. causes hypo and hypoerglycemia.

Answer 7

Gatifloxacin

Question 8

Second generation Quinolone for Mycoplasma, Chlamydia, and Legionella.

Answer 8

Levofloxacin

Question 9

This generation of Quinolones prolongs the QT interval.

Answer 9

Second generation Quinolones

Question 10

Active againt gram negatives like Pseudomonas and Anthacis

Answer 10

Ciprofloxation

Question 11

First generation Quinolone

Answer 11

Ciprofloxacin

Question 12

Quinolone Adverse Reactions

Answer 12

• Cartilage damage.
• Can’t use in kids.
• Tendonitis
• Poor oral absorption if chelated with a cation.
• Cause C. difficile
• Increased amount of Theophylline in the blood.
• Seizure

Question 13

Clinical use of Quinolones

Answer 13

Community acquired pneumonia

Question 14

This generation of quinolones is good for pneumonia.

Answer 14

Second generation.