Antibiotic Drugs Flashcards

1
Q

What are the two (2) most important goals of HAART?

A

Decrease HIV load and increase CD4 levels

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2
Q

It inhibits helminth-specific enzyme

A

Thiabendazole

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3
Q

What is the term used to described fungal infection?

A

Mycosis

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4
Q

What is Tuberculosis?

A

It is characterized by granulomas in the lungs from accumulation of inflammatory cells with a cheesy caseated consistency

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5
Q

What is a Multi-Drug Resistant TB?

A

It is a tuberculosis that demonstrates resistance to two or more drugs

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6
Q

What are the different types of Tuberculosis?

A
  • M. Tuberculosis
  • M. leprae
  • M. avium-intracellulare
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7
Q

What are the host factors?

A
  • Immune system
  • Site of infection
  • Age
  • Pregnancy
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8
Q

It is used for organisms where resistance is common, to test for sensitivity of the organisms to various antimicrobials

A

Sensitivity

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9
Q

What is an Empiric Therapy?

A

It is when a drug selected is known to be the best drug that can kill the MO

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10
Q

What is a Definitive Therapy?

A

Once the MO is identified in the lab, the antibiotic therapy is tailored by using the most narrow-spectrum, least toxic drug based on C&S results

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11
Q

It is when signs and symptoms do not improve

A

Subtherapeutic

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12
Q

It occurs when the antibiotics reduce or completely eliminate the normal bacterial flora

A

Superinfection

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13
Q

What is a narrow spectrum?

A

It is primarily effective against one type of organism (selective)

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14
Q

What is a broad spectrum?

A

It is effective against gram-positive and gram-negative organisms

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15
Q

It is equal to the sum of the effects of two antibiotics

A

Additive Effect

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16
Q

It occurs when one antibiotic increases the effectiveness of the 2nd drug

A

Potentiative Effect

17
Q

It is when two drugs are used together; the desired effect may be greatly reduced

A

Antagonist Effect

18
Q

What happens when a bacterium is sensitive to the drug?

A

The pathogen can be inhibited or destroyed

19
Q

What happens when a bacterium is resistant to the drug?

A

The pathogen will continue to grow despite administration

20
Q

What are the five (5) mechanisms of antibacterial action?

A
  1. Inhibition of bacterial cell-wall synthesis
  2. Alteration of membrane permeability
  3. Inhibition of protein synthesis
  4. Inhibition of the synthesis of bacterial RNA and DNA
  5. Interference with metabolism within the cell