Antibacterial Prescribing

Question 1

What is the difference between empiric and pathogen directed antibiotic choice?

Answer 1

Empiric - is typically drugs that cover a large spectrum without much specificity
pathogen directed is prescribing a drug with likely pathogen in mind for that location.

Question 2

What are common reasons for drug failures?

Answer 2

Drug Choice - wrong susceptibility for site of infection, emergence of resistance, and multiple organism infection
Host Factors - host suppressed immune response, medical devices housing infection, and/or abscess of infection

Question 3

What are the factors needed to consider for abx choice?

Answer 3

• Resistance pattern
• Age
• Renal/Liver function
• Route (IV, IM, PO)

Question 4

What are the common drug treatments for UTIs?

Answer 4

1st Choice - TMP/SMX

2nd Choice - Nitrofurantoin, Fosfomycin, Ciprofloxacin

Question 5

What are common drugs used to treat MRSA?

Answer 5

Vancomycin
Linezolid
Daptomycin
Tigecycline

Question 6

Common treatment options for community acquired MRSA?

Answer 6

Oral Drugs primarily used for outpatient treatment

• Linezolid
• Doxycyline/Minocycline
• Clindamycin
• TMP/SMX