Antiarrythymic Drugs

Question 1

Types of cardiac arrhythmia

Answer 1

1. Atrial flutter
2. Atrial fibrillation
3. Supra ventricular tachycardia

Question 2

Classification (Vaughan Williams)

Answer 2

Class 1. Sodium channel
PROLONG REPOLARIZATION
— Quinine, procinamide, disopyrmide.

      SHORTEN REPOLARIZATION
      ---Lignocaine ,mexiletine, phenytoin

     LITTLE EFFECT ON REPOLARIZATION 
      ---Encainide, Flecainide,Propafenone

Class 2. B-adrenergic blocker
REDUCE SYMPATHETIC TONE
—Propranolol, acebutolol , esmolol

Class 3. K+channel blocker
PROLONG REPOLARIZATION
— Amiodarone,Dronadar one,vernakalant,bretylium,sotalol, dofetilide,ibutilide

Class 4. Ca+2 channel blocker
PROLONG CONDUCTION AND REFRACTORINESS IN SA AND AV NODES
— Verapmil,Diltiazem