Antiarrhythmic drugs

Question 1

what is the most common cause of death in MIs and terminal HF

Answer 1

Arrhythmias

Question 2

what medications are used for arrythmias

Answer 2

class I: na+ channel blockers
class II: beta blockers
class III: k+ channel blockers
class iv: Calcium channel blockers

Question 3

class 1a

Answer 3

moderate na+ channel blockers
increase AP duration

Question 4

class 1b

Answer 4

mild na+ channel blockers
decrease AP duration
ex: lidocaine

Question 5

class 1c

Answer 5

marked na+ channel blockers
no effect on AP duration

Question 6

class II

Answer 6

beta blockers

good for arrythmias causes by over activation of sympathetic effects

Question 7

which drug is used prophalactic after MI

Answer 7

propanolol

Question 8

class III

Answer 8

k+ channel blockers

Question 9

Amiodarone

MOA:
USE:
AE:

Answer 9

MOA: k+ channel blocker. prolongs AP and refractory period

USE: many types of arrhthymias
AE: thyroid abnormalities
skin deposits, optic neuritis, pulmonary fibrosis

Question 10

what is the most efficacious anti arrthymia drug

Answer 10

amiodarone

Question 11

class IV

Answer 11

calcium channel blockers

Question 12

when should CCBs be avoided

Answer 12

in ventricular arrthymias

Question 13

which type of CCB is useful in arrthymias

Answer 13

non-DHP

DHP not useful in arrthymias

Question 14

which drug is commonly used in a fib

Answer 14

diltiazem

Question 15

which class should be used in atrial and ventricular arrythmias

Answer 15

class I and III

most affect the myocytes AP

Question 16

which class should be used for atrial and nodal arrythmias

Answer 16

Class II and IV

mostly affect the nodes

Question 17

when is potassium helpful

Answer 17

in digitalis induced arrthymias and arrhytmias associated with hypokalemia

-slows ectopic pacemakes and conduction velocity in the heart