Antianginal drugs

Question 1

Nitroglycerin

MOA
USE
AE

Answer 1

MOA: releases NO which increases cGMP, which relaxes vascular SM

USE: acute angina pectoris , rapid onset
AE: hypotension, H/A, blurred vision, dry mouth, tachycardia

Question 2

contraindications with nitroglycerin

Answer 2

-hypersensitive to nitrates
-severe brady or tachy cardia
-use of PDE-5 inhibitors (viagra)

Question 3

duration of action of nitroglycerin

short:
med:
long:

Answer 3

short: sublingual 10-20 min
med: oral 2-4 hours
long: transdermal 8-10 hours (prophylaxis)

Question 4

which type of antianginal drug should be avoided in heart failure

Answer 4

calcium channel blockers

Question 5

which is more selective type of vascular L-type ca+ channel blocker

Answer 5

Dihydropridines are more selective and cause less cardiac depression than non DHPs

Question 6

Amlodipine

MOA:
USE:
AE:

Answer 6

MOA:DHP calcium channel blocker
USE: angina, HTN
AE: pretibial edema, hypotension cardiac depression , flushing, dizziness

Question 7

Verapamil

MOA:
USE:
AE:

Answer 7

MOA: non-DHP CCB
USE: stable angina, HTN, av nodal arrythmias, migraines
AE: constipation,pretibial edema, hypotension cardiac depression , flushing, dizziness

Question 8

what do calcium channel blockers do? who should avoid them?

Answer 8

they increase the contractility of the heart

should be avoided in heart failure

Question 9

can beta blockers can be used in angina

Answer 9

yes

Question 10

maintance therapy for chronic/stable angina

Answer 10

-long acting nitrates
-CCBS or BB may be used

Question 11

maintance therapy for hypertensive pts with angina

Answer 11

mono-therapy w either slow-release or long acting CCBs or BBs

Question 12

maintanance therapy for vasospastic angina

Answer 12

nitrates and CCBs

beta blockers are not effective fot vasospastic angina

Question 13

are beta blockers effective for vasospastic angina?

Answer 13

no