Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Pharm MT2 > Antianxiety flash > Flashcards

Antianxiety flash Flashcards

1
Q

What are the benzodiazepines?

A

Antianxiety drugs “pams and lams”

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

What are the benzodiazepines primarily used to treat anxiety - longer duration?

A

Chlordiazepoxide, diazepam, alprazolam, clonazepam, clorazepate, oxazepam, lorazepam.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

What are the benzodiazepines primarily used to treat insomnia? shorter duration

A

Flurazepam, temazepam, estazolam, quazepam, triazolam

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Which benzodiazepine is used in surgery?

A

Midazolam

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

What is the mechanism of action of benzodiazepines?

A

Can increase GABAergic neuron activity - bind to GABA receptor and make it more sensitive to GABA (limited by amount of GABA available)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

What is the therapeutic index of benzodiazepines?

A

Very high

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

What is flumazenil?

A

Benzodiazepine receptor blocker (BEN is off with the FLU)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

How is flumazenil administered?

A

I.V. (1st pass effect)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

What are the non benzodiazepine hypnotics used for?

A

Only for sleep

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

What are the non benzodiazepine hypnotics?

A

Z drugs zolpidem, zaleplon, eszopiclone.meprobamate, ramelteon, buspirone.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

What is the mechanism of action of non benzodiazepine hypnotics?

A

Act on benzodiazepine receptors at a different site than benzodiazepines

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

What is a concern with meprobamate?

A

(OBAMA) strong interaction with ethanol which can often lead to accidental suicide

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

What is the mechanism of action of ramelteon?

A

raMELteon - Melatonin receptor agonist. Reduces time to onset of sleep by several minutes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

What is the mechanism of action of buspirone?

A

Partial serotonin receptor agonist

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

What is buspirone primarily used for?

A

Antianxiety - not sedative or hypnotic

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

What are the barbiturates?

A

The “itals” antianxiety/sedation/hypnotic (do it all)

17
Q

What are some of the barbiturates?

A

Pentobarbital/secobarbital (3-4 hours of duration), butabarbital/amobarbital (6-8 hours of duration), mephobarbital/*phenobarbital (10-16 hours of duration)

18
Q

What is the mechanism of action of the barbiturates?

A

Enhance GABA effect - efficacy&raquo_space; the benzodiazepines

19
Q

What are some problems associated with barbiturates?

A

Depressed respiration - used in suicide attempts, induces p450, suppression of REM sleep leading to REM rebound

20
Q

What is chloral hydrate?

A

Knockout drops good for inducing but not maintaining sleep

21
Q

What are antihistamines that are good for inducing sleep?

A

Diphenhydramine and hydroxyzine

Pharm MT2 (4 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions