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Pharm MT2 > Anti-elipleptics flash > Flashcards

Anti-elipleptics flash Flashcards

1
Q

What is the drug class of phenytoin?

A

Agents used to treat Gran Mal and partial seizures

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2
Q

What is the mechanism of action of phenytoin?

A

Inhibits sodium channels

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3
Q

What are side effects of phenytoin?

A

Acute - respiratory depression, vertigo, ataxia, gingival hyperplasia, hirsutism, ataxia, diplopia, sedation

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4
Q

What is the drug class of carbamazepine?

A

Used for partial seizures except petit mal

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5
Q

What is the mechanism of action of carbamazepine?

A

Inhibits sodium channels

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6
Q

What are side effects of carbamazepine?

A

Visual effects, drowsiness, fetal defects (spinal bifida)

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7
Q

What is the drug class of phenobarbital?

A

Barbiturate used to treat all seizures but petit mal

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8
Q

What is the mechanism of action of phenobarbital?

A

Activates GABAergic neurons - strong sedative and induces p450

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9
Q

What is the drug class of diazepam?

A

Benzodiazepine used to treat seizures.

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10
Q

What is the mechanism of action of diazepam?

A

Activate GABA neurons

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11
Q

What is the mechanism of acetazolamide?

A

Carbonic anhydrase inhibitor

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12
Q

What drugs are used to treat petit mal?

A

Ethosuximide and sodium valproate

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13
Q

What is the DOC for petit mal seizures?

A

Ethosuximide

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14
Q

What is the mechanism of action of ethosuximide?

A

Ca2+ channel inhibition

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15
Q

What type of seizures is sodium valproate used for?

A

All seizure types

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16
Q

What is the mechanism of action of sodium valproate?

A

Act on Na+/Ca++ channels. Decrease GABA metabolism and increase GABA synthesis

17
Q

What are the drugs used to treat partial seizures which act by increasing GABA?

A

Topiramate, gabapentin, tiagabine, vigabatrin

18
Q

What are the drugs used to treat partial seizures which act on Na+ channels?

A

Lamotrigine, zonisamide, rufinamide, lacosamide.

19
Q

What is the drug class of pregabalin?

A

Used to treat partial seizures

20
Q

What is the mechanism of action of pregabalin?

A

Blocks Ca2+ channels

21
Q

What is the drug class of ezogabine?

A

Agents used to treat partial seizures

22
Q

What is the mechanism of action of exogabine?

A

Blocks Ca2+ channels

23
Q

What drug is used to treat status epilepticus?

A

Diazepan is DOC

Pharm MT2 (4 decks)

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