Anti Psychotic Drugs

Question 1

Neuroleptics usages (illnesses)
1-
2-
3-
4-

Answer 1

Bipolar
Schizo
Delusional disorder
Psychotic depression

Question 2

Antipsychotics or—– are also used to treat ——-
Term neuroleptic is called for:
1-
2-
3-

Answer 2

Major tranquilizers
OCD
1-antagonism of D2 dopamine receptors
2- substantial risk of extrapyramidal side effects
3-increased release of prolactin

Question 3

Therapeutic actions of neuroleptics

Answer 3

Sedative
Anti positive symptoms
Anti negative symptoms

Question 4

Typical antipsychotics mechanism of action
1-
2-
3-

Answer 4

1-Dopamine d2 receptor blockage in mesolimbic and mesocortical for antipsychotic effects
2-dopamine d2 receptor blockage in basal ganglia for EPS side effect
3-dopamine d2 receptor supetsensitivity in nigrostriatal system for tardive dyskinesia

Question 5

Typical neuroleptics produce a general depression in the CNS

Answer 5

False

Question 6

No development of abuse addiction with no delay of action

Answer 6

False
There is a delay in action

Question 7

Names of typical antipsychotics
1-
2
3-

Answer 7

Phenothiazines (2 benzene 1 sulfer 1 nitrogen)
Thioxanthenes

Question 8

Phenothiazines subgroups
Side effects by ——-:—–,—-,—-
Those with aliphatic side chains include—– with
1-
2-
3-

Answer 8

Blocking receptors
M1 H1cand alpha1
Chlorpromazine
EPS side effects ++
Muscarinic ++
Sedation and hypotension +++

Question 9

With piperidine ring include ——
EPS side effects —–
Muscarinic side effects—–
Sedation or hypotension—–

Answer 9

Thioridazine
+
+++
+++

Question 10

Piperazine group include—–
Eps—-
Muscarinic—-
Sedation or hypotension—-

Answer 10

Fluophenazine
+++
++
+

Question 11

Thioxanthenes have —- or —– side chains
The analog of chlorpramazine in thioxantheens is —–
Analog of piperazine in thioxanthates is ——/

Answer 11

Aliphatic
Piperazine
Chlorprothixene
Flupentixol

Question 12

Thioxanthans are potent tranquilizers

Answer 12

True

Question 13

Butyrophenone include—- dericative of analgesic——
Side effects:

Answer 13

Haloperidol
Meperidine
Confusion weight gain gynecomastia galactorrhea and neuroleptic malignant syndrome

Question 14

Adverse effects of antipsychotics

Answer 14

Blockage of M1: dry mouth urinary retention consptipation tachy impotence blurred vision
Blockage of H1: sedation weight gain
Blockage of aloha 1: hypotension and arrythmias
Blockage of D2: EPS side effects prolactenemia gynecomastia and galactorrhea
Leukopenia agranulocytosis
Photosensitivity with phenothiazines

Question 15

EPS side effects
Due to——-
1-
2-
3-

Answer 15

Excess of cholinergic and inhibition of dopamine
Dystonia (few hrs to days of tx)
Akathisias (within days to weeks)
Parkinson like symptoms (weeks to months)

Question 16

Parkinson like syndrome:

Answer 16

Bradykinesia
Tremors
Hypertonia

Question 17

In many individuals Tardive dyskinesia is ——- after discontinuation of tx it may occur after —– to — of tx
Caused by——–

Answer 17

Irreversible
Months to years
Increased dopamine receptors by compansatory mechanisms which make it supersensitive and overpower the cholinergic input

Question 18

Neuroleptic malignant sundrome
Occur —– to —— hr when—— especially with ——- and —–
Symptoms:

Answer 18

24 hr to 72 hr when elevated doses are administered
Butyrophene and phenothiazianes
Akinesia
Muscle rigidity
Fever
Altered muscle statur and stupor
Unstable Bp
Other