Anti-lipidemic medications Flashcards
Why is cholesterol important in the body?
Normal function→ cholesterol is used to make hormones, maintain cell membrane integrity and make bile acids
hepatocytes have LDL receptors which pull LDL out of circulation for packaging
What are the 7 classes of medications used in hyperlipidemia?
- -> HMG CoA Reductase Inhibitors (Statins)
- -> Fibrates
- -> Bile Acid Sequestrents/ Resins
- ->Cholesterol Absorption inhibitors
- -> Niacin
- -> PCSK9 inhibitors
- ->vOmega-3s
What are examples of HMG CoA Reductase Inhibitors (Statins)?
Atorvastin, pravastatin, simvastatin, lovastatin, rosuvastatin
What is the mode of action for HMG CoA Reductase Inhibitors (Statins)?
up regulates LDL receptors (creates more LDL receptors)
What is the effect of HMG CoA Reductase Inhibitors (Statins)?
Lowers LDL
Raises HDL
What are adverse effects of HMG CoA Reductase Inhibitors (Statins)?
Rhabdomyolysis (Rhabdo occurs when damaged muscle tissue releases its proteins and electrolytes into the blood)
What are examples of Fibrates?
Gemfibrozil, fenofibrate
What is the effect of fibrates?
Lowers Triglycerides
a type of fat (lipid) found in your blood
What are the adverse effects of fibrates?
GallStones
What are examples of Bile Acid
Sequestrents/ Resins?
Colestipol, cholestyramine****
cholesterol
What is the mode of action of bile acid sequestrents/resins?
Binds bile acids, preventing absorption
What is the effect of Bile Acid sequestrents/Resins?
Lowers LDL
What is the adverse effect of bile acid sequestrents/resins?
GALL stones
What are examples of cholesterol absorption inhibitors?
Ezetimibe
What is the mode of action for Cholesterol Absorption inhibitors?
Decreases absorption of cholesterol and LDL into the body
