Anti-coagulants

Question 1

What are the types of anticoagulants?

Answer 1

(Heparin)
Heparin
LMWH
Synthetic

(other)
Factor X/Xa inhibitors

Direct thrombin (Factor II) inhibitors

Vitamin K reductase inhibitor

Question 2

What are examples of heparin medications?

Answer 2

Heparin

Question 3

What is the antidote to heparin?

Answer 3

Protamine sulfate

Question 4

Where is Antithrombin III made?

Answer 4

Liver

Question 5

What is an example of Factor X/Xa inhibitors?

Answer 5

Apixaban, rivaroxaban (note the Xa in the name!)

Question 6

What is the MOA of Factor X/Xa inhibitors?

Answer 6

Inhibits Factor X/Xa

*factor X to factor Xa which is clotty)

Question 7

What are examples of Direct thrombin (Factor II) inhibitors?

Answer 7

Univalent: argatroban and dabigatran
Bivalent: bivalirudin, desirudin

RUDIN

Question 8

What is the MOA of Direct thrombin (Factor II) inhibitors?

Answer 8

Univalent: bind only to active siteBivalent: bind to active site and ”pre-active” site

Question 9

What is an example of a vitamin K reductase inhibitor?

Answer 9

Warfarin

Question 10

What is the MOA of vitamin K reductase inhibitor?

Answer 10

inhibits activation of several factors in the cascade (VII, IX, X, II) through inhibition of vitamin K recycling (often used with heparin therapy)

Question 11

What is the antidote of vitamin K reductase inhibitors?

Answer 11

Vitamin K

Question 12

What does heparin act on?

Answer 12

Acts on anti-thrombin

Question 13

What is the antidote for warfarin?

Answer 13

Antidote: Vit K
Oral administration
Lots of DDIs and D-Food Inx, narrow therapeutic window, requires close monitoring