Anti-inflammatory Drugs and DMARDS Flashcards
1
Q
Anti-inflammatory drugs
A
Inhibit the cyclooxygenase [COX]
2
Q
COX
A
Responsible for the formation of prostaglandin
3
Q
Function of prostaglandins
A
Pain and inflammation
4
Q
COX - 1
A
Protective lining of the stomach
5
Q
COX-2
A
Pain and inflammation
6
Q
Non selective NSAIDS
A
Inhibit both COX-1 and 2
7
Q
Examples of non-selective NSAID
A
- Aspirin
- Ibuprofen
- Ketoprofen
- Naproxen
- Mefenamic Acid
8
Q
Side effects of Non-selective NSAIDS
A
- Gastric upset
- gastric ulceration
- gatric bleeding
9
Q
Selective NSAID
A
- Inhibit COX-2; spared COX-1
- COX-2 NSAID
10
Q
Side effect of selective NSAID
A
- Cardiac Arrest
- Stroke
11
Q
COX-1
A
Protective lining of the stomach
12
Q
Thromboxane (cox-1)
A
- increases the activity of platelets
13
Q
Prostaclyclin (cox-2)
A
- for vasodilation
- inhibit platelet aggregation in the corpnary artery and carotid artery
14
Q
Corticosteroids/Glucocorticoids
A
- endogenous steroids (androgen and cortisol)
- stimulates the leukocytes and macrophages
15
Q
Examples of corticosteroids
A
- cortisone
- prednisone
- prednisolone
