Anti Inflammatory

Question 1

RA

Answer 1

Condition when white blood cells view self tissue as non self. Initiates an autoimmune response.

Question 2

Prostaglandins

Answer 2

Lipid compounds that have hormone like effects. Act locally on the tissues in which they are made. Rapidly metabolized.

Many different biological activities based on which receptor is activated- could be agonist or antagonist.

Question 3

All NSAIDS work by

Answer 3

Inhibiting the synthesis of prostaglandins.

Question 4

How are prostaglandins made starting with phospholipids?

Answer 4

Phospholipids converted to arachidonic acid by phospolipiase A2.

Then AA can be used for either the lipooxygenase pathway or cyclooxyrgenase pathway. This produces COX 1 and COX 2, which both release prostaglandins.

Question 5

COX 1

Answer 5

Responsible for regulatory and protective prostaglandins.

Question 6

COX 2

Answer 6

Prostaglandins caused elevated production in sites of chronic disease and inflammation. heat, swelling, redness, pain.