Anti-inflammatories

Question 1

List the COX pathway

Answer 1

Membrane phospholipid
(phospholipase A2)
Arachidonic acid
(COX-1 or COX-2)
PGG2
PGH2- thromboxanes, prostaglandins, prostacyclin

Question 2

Difference between COX1 and COX2

Answer 2

COX1- isoleucine amino acid lining its channel

COX2- valine instead, smaller amino acid, meaning wider channel

Question 3

What are the 3 main types of NSAIDS, and what do all NSAIDS do

Answer 3

Aspirin
Paracetamol
Ibuprofen
They inhibit COX, thereby limiting the production of various inflammatory mediators

Question 4

Effects and side-effects of NSAIDS

Answer 4

1.Decrease vasodliation
2.Good analgesics
3.Antipyretic drugs
SIDE FX
1.Dyspepsia, nausea, ulceration etc.
2.Renal failure
3.Liver damage

Question 5

Types of anti-rheumatic drugs

Answer 5

Methotrexate
Sulfasalazine
Ciclosporin
Glucocorticoids 
Biopharmaceuticals?

Question 6

Pathway of IgE mediated hypersensitivity

Answer 6

1. individual becomes sensitised (IgE antibodies bind tightly to IgE Fc receptors)
2. Degranulation

Question 7

Treatment of asthma

Answer 7

Beta agonists (bronchodilators)
Glucocorticoids
immediate phase drugs 
late phase drugs 
biological drugs