Analgesia

Question 1

What do DRG neurons do?

Answer 1

Convey sensory info from the periphery to the spinal cord

Question 2

What are 3 types of pain

Answer 2

Acute
Chronic
Neuropathic

Question 3

3 types of analgesic drugs

Answer 3

1. NSAIDS
2. Paracetamol
3. Opioids

Question 4

What are analgesics aimed at?

Answer 4

The pain circuit
DRG and spinal horn neurons
Pain processing areas of the brain

Question 5

2 problems associated with NSAIDs

Answer 5

1. CV risk

2. gastrointestinal risk (ulceration, bleeding)

Question 6

3 problems associated with opioids

Answer 6

1. Sedation
2. Depression of respiration (overdose)
3. Inhibition of gastrointestinal tract

Question 7

What are the 4 opioid classes. Name the most common in each class

Answer 7

1. Natural- morphine
2. Semi synthetic- heroin
3. Synthetic- fentanyl
4. Endogenous- endorphins

Question 8

What are 3 new approaches for analgesics?

Answer 8

1. Blocking specific Nav channels
2. Monoclonal antibodies (against nerve growth factor)
3. BOTOX