Anti-inflammaotry Drugs Flashcards
What are anti inflammatory drugs
Inflammation of some kind associated with all pathogens and non-pathogenic diseases
Symptoms of inflammation
Swelling and redness
Heat and fever
Pain
What does acute inflammation secrete
TNF-A, IL-1 IL-6
Name soem anti-inflammatory drugs
Antihistamines
Corticosteroids
NSAIDs
What is histamine
Nitrogenous compound
What is the main histamine receptors
H1
What is h1 present on
Immune cells such as macrophages, nuetrophils
What does histamine binding to hq contribute to
Vasodilation
Sensory nerve ending/pain/itching
Increase capillary permeability
What do anti-inflammatory anti-histamines target
Histamine - h1 receptors
H1 receptor agonist and reverse agonists
What are the uses of antiinflammatoreis
Allergies, itching, swelling
What are the main classes of corticosteroids
Mineralcoricoids
Glucocorticoids
What are the activities corticosteroids so to reduce inflammation
Reduce cytokine production
Reduce prostaglandin production
Very powerful immunosuppression
What is transgression of corticosteroids
Bound glucocorticoid on receptor
Gr moves into nucleus
Interferes with other TF - decrease pro inflammatory proteins
Binds to NF-KB element and GR cells switch it off
Reduces mRNA production
What is transactivaton of corticosteroids
GR attatched to receptor moves into nucleus
Regulates gene expression
Increases anti-inflammatory protein
GR attatches to glucocorticoids response element
Leads to upregulation of I-KB
InhibitsNF-KB
What is NSADS mode of action against
Prostaglandins
What are NSAIDS defined by
Inhibition of one or more steps in the metabolism of arachnoid acid AA
What is acute inflammation
Primary response to microbial, chemical or physical injury
What is chronic inflammation
Follows acute inflammation
If offending material is not destroyed then continual of a macrophages and fibroblasts occurs
Complications of antihistamines
First gen antihistamines - cause drowsiness and be fatal
Second generation antihistamines - less sedative but not useful in controlling prurits ad are you cardiotoic at high doses
What do glucocorticoids do
Everything
Reduce swelling
Pain
Histamine
Vsolidation
Reduces everything
Complication of glucocorticoids
Suppress wound healing
Gastric ulceration
Skin tinning if used topically
Glucocorticoids use
Allergic disease -asthma
Life threatening swelling - laryngeal oedema
Shock
Autoimmune disease
Complications of NSAIDS
Gastrointestinal bleeding
Poor wound healing
Uses of NSAIDs
Control of pain
Decrease swelling
Reduce fever
What are tricyclic antidepressants mode of action
Recieved at synaptic cleft brings serotonin back up the axon and stops the transporters from taking in serotonin transmitters
What are benzodiazepines
Enhances GABA binding to GABA receptors - blocks impulses between nerve cells in the blend - reduce the likelihood of nuerons firing an action potential
Pheromones mode of action
Animals will actively pump Vomeronasal organ -
Wind sucking in horses etc
Causes G proteins to bind to the vomronasal organ
What is the anaesthesia triad
Analgesia
Muscle relaxation
Control
How do you gain general anesthesia
By using all 3 t sections of the triad = may have to use one or more anasthesia drug
What are barbituates mode of cation
