Anti-fungals And Anti-virals Flashcards
Do antibiotics have an effect on fungi?
Most dont
What are fungi split into?
Yeast and filamentous fungi (moulds)
What are the 4 main classes of anti-fungals?
Polyenes, Azoles, allylamines, echinocandins
What is an example of a polyene?
Amphoterecin B
When would Amphotericin B be used, administration and why?
Its a polyene anti-fungal. Used in serious cases as its toxic, via IV administration. Against yeasts and moulds.
What is an example of an azole?
Fluconazole
What is the role of fluconazole?
Treats yeast infections like candida. Inhibits ergosterol synthesis
What is an echinocandin and its role
Micafungin. For serious candida (yeast infections)
What is an allylamine and its role?
Terbinafine. Inhibits ergosterol synthesis. Treats athletes foot and ringworm topically. Orally in serious cases
Do antibiotics have any action against viruses?
Not at all
What action do anti-virals have on viruses?
All virustatic - none virucidal. Many interfere with nucleic acid synthesis
How is HIV treated? Why?
Using 3 anti-virals - combination therapy. The drugs are active on at least 2 phases of HIV replication
Zidovudine, Saquinavir, Nevirapine
What are 2 types of herpes?
HSV and VZV
Herpes simplex virus
Varicella zoster virus
What is an anti-Herpes drug and how is it administered? What’s a benefit of using this drug?
Aciclovir. Orally or topically. Has low toxicity on uninfected cells
Which 2 drugs can treat hep B and C?
Interferon A for both. Ribavirin for hep c
