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anti-epileptics Flashcards

1
Q

dose of phenytoin

A

LD: PO 1000mg 2-4 doses in 12-24h
IV: 1000-1500mg

maintain 300-400mg/d

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2
Q

carbamazepine

A

LD: 100mg BD
MD: 400-1600mg/d in 3-4 doses

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3
Q

oxacarbazepine

A

LD: 300md BD
LD: 600-2400mg/d in 2 divided does

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4
Q

phenobarbital

A

LD: 180mg BD 3d
MD: 90-180mg once

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5
Q

lamotrigine

A

LD: 25mg BD
MD: 250-500mg/d

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6
Q

levetiracetam

A

LD: 250-500mg BD
MD: 1000-3000mg/d in 2 divided doses

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7
Q

topiramate

A

LD: 25mg/d
BD: 100-400mg in 2 divided doses

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8
Q

self harm

A

topiramate, leve, vigabatrin

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9
Q

SJS

A

carba, phenytoin, phenobarbital, lamotrigine, oxacarbamazapine

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10
Q

decreased folate

A

carba, phenytoin, gaba

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11
Q

decrease b12

A

phenobarbital, topiramate, pregabalin

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12
Q

phenytoin ADR

A

dose related: diplopia, ataxia, gingivial, hirsutism, coarse facial features, osteomalacia, megaloblastic anaemia
idiosyncratic: rash, sjs, fever, hepatic, blood dysfunction

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13
Q

carbamazepine ADR

A

dose related: diplopia, ataxia, GI, sedation
idiosyncratic: sjs, rash, blood dysfunction, hepatic, SIADH

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14
Q

phenobarbital ADR

A

dose related: sedation, insomnia, behaviour, diplopia,
idiosyncratic: rash sjs

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15
Q

valproate ADR

A

dose related: GI, tremor, sedation, weight gain, hair loss, thrombocytopenia
idiosyncratic: hepatic, peripheral edema, pancreatitis

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16
Q

topiramate ADR

A

dose related: confusion, ataxia
idiosyncratic: glaucoma, rectal stone

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