Anti-Clotting Drugs Flashcards
how does heparin and LMWH work?
utilizing anti thrombin they inhibit action of thrombin and factor Xa
how must heparins be administered?
IV or sub Q due to large molecular weight
what does fondaparinux target and inhibit?
factor Xa
name the two other thrombin inhibitors aside from heparin that are administered IV or SubQ?
argatroban and bivalirudin
name the thrombin inhibitor that is administered orally?
dabigatran
name the three factor Xa inhibitors taken orally
APixaban
Rivaroxaban
Edoxaban
how does warfarin work?
vitamin K reductase inhibition so decreases factor 2,7,9,10 and protein C/S….
what must you do with warfarin treatment?
heparin bridge
can you give warfarin when pregnant?
NO
what molecule does aspirin prevent production of that plays key role in platelet activation?
thromboxane 2
name the three P2Y12 inhibitors
clopidogrel
prasugrel
ticagrelor
what molecule do P2Y12 inhibitors affect that decreases platelet activation?
ADPases
name the three GPIIb/IIIa inhibitors
abciximab
eptifibatide
tirofiban
explain the mechanism of GPIIb/IIIa inhibitors
they prevent the platelets from aggregating with each other
what does tissue plasminogen activator do?
breaks up clots by activating plasminogen into plasmin
