Anti- Bacterials Flashcards
what are the two antibacterials you could use
cholromphenicol
and fusidic acid
in the uk most common line of antibacterial used is chloramphenicol because of the cost (it is much cheaper)than fusidic acid
what are the antibacterials used for
used in the treatment of bacterial conjunctivitis typically on acute presentation
what presentations of conjunctivitis wont respond to antibacterials
viral forms of conjunctivitis particularly those from Adeno virus
what are the two antimicrobial drugs available for orthoptists
the only anti microbial made available to orthoptists are antibacterial drugs and of these two are available for the treatment of acute bacterial conjunctivitis and the prophylactic management of corneal abrasion
what dosage of chloramphenicol can you use
0.5% minims or 1% ointments , P medicine when supplied to children over 2 years old and adults. POM in under 2 years
what dosage of fusidic acid is used
1% modified release. Contains benzalkonium chloride as preservative, very expensive so considered as second line medication or in cases of known chloramphenicol contraindication
how prevalent is ABC (acute bacterial conujuctivits)
approximately 78% of acute infectious conjunctivitis in children are cases of bacterial conucitivits (Chen et al 2023)
what does acute bacterial conjuctivitis present as
usually presents as bilateral pink eye (due too conjunctival infection) with mucopurlent discharge
the lids are typically stuck together overnight and the discharge forms and dries so crusting on the lashes
the vision is not affected (or only minimally due to compromised tear film) and the eye maybe irritable, but no painful
anterior chamber is clear and there are no associated lymph andenopathies
it is not usually associated with an unwell child (unlike viral conjuctvitis) which may co present with a febrile child
what history would you expect with a presentation of acute bacterial conjunctivitis
due to the highly contagious nature of the disease, there may be history of recent contact with a person who had bacterial coonjuvitis , it is most commonly spread through contaminated fingers , thus emphasising the importance of hand hygienie to those diagnosed with an acute bacterial conjcutvitis
what is important for diagnosis
the accurate diagnosis of acute bacterial conbjcutivits is essential and the practiser must rule out potentially sight threatening disease prior to arriving at a diagnosis
if necessary , this may require obtaining a conjunctival culture and is particularly important for infectious neonatal conjucvitics , when an ophthalmologist opinion Is imporant
how long do the signs of acute bacterial conjunctivitis typically last
they usually last less than three- 4 weeks
what are the most common pathogens involved in acute bacterial conjuctiits for adults and childreen
the more common pathogen for adults in staphylococcus aureus whereas sreptoscocculs p neumonaie
what does the department of health say about acute bacterial conjunctivitis say about treatment
acute bacterial conjunctivitis is a self limiting disease nd is not sight threatening it will resolve without intervention in approximately 7-10 days (department of health)
presents a problem of supplying an antimicrobial to the parent or carer or wait remission of the infection without intervention
what concerns does treating acute bacterial conjunctivitis with antimicrobials rise
antimicrobial resistance
Antimicrobial resistance (AMR) refers to the ability of microorganisms, such as bacteria, viruses, fungi, and parasites, to evolve and develop resistance to the drugs or antimicrobial agents that were originally effective at treating infections caused by these microorganisms. In other words, these microorganisms become resistant to the drugs that were once able to kill or inhibit their growth.
Antimicrobial resistance is an escalating problem (NICE, 2015) and is given due attention in the Department of Health in “UK Five Year Antimicrobial Resistance Strategy 2019 to 2024” (Department of Health, 2019).
In this document the strategies ‘optimising prescribing practice and improving professional education, training and public engagement are of particular relevance here
what does evidence say about treating conjcutivits with antimicrobials
it was found that the use of antimicrobials were benefit in improving early (days two - five) clincial and microblogical remission rates
at the ‘‘late’’ time point (days six to 10) antibitocs were also showing a modest improvement in clinical and microbiological remission rates
it should be noted that neither course of treatment was associated with any severe ocular outcomes