Anti-Arrhythmics

Question 1

Class that interferes with Na Channels?

Answer 1

Class I (Na Channel Blockers)

Question 2

Agents are anti-sympathetic nervous system agents. Most agents in this class are beta blockers?

Answer 2

Class II (Beta Blockers)

Question 3

Agents that affect potassium (K+) efflux

Answer 3

Class III (K Channel Blockers)

Question 4

Agents that affect calcium channels and the AV node.

Answer 4

Class IV (CCBs)

Question 5

Agents work by other or unknown mechanisms.

Answer 5

Class V

Question 6

(Na+) channel block (intermediate association/dissociation) and K+ channel blocking effect? Quinidine

Answer 6

Class Ia

Question 7

Na+ channel block (fast association/dissociation)- Lidocaine

Answer 7

Class Ib

Question 8

Na+ channel block (slow association/dissociation)- Encainide

Answer 8

Class Ic

Question 9

Beta Blocking (beta adrenergic antagonist) propranolol also shows some class I action

Answer 9

Class II

Question 10

K+ Blockers– Amiodarone has Class I, II, III & IV activity

Answer 10

Class III

Question 11

CCBs- Verapamil-Slow Channel Blockers

Answer 11

Class IV

Question 12

Work by other or unknown mechanisms (direct nodal inhibition)- Adenosine

Answer 12

Class V

Question 13

Medical uses as:

• Ventricular Arrhythmias
• Prevention of paroxysmal recurrent atrial fibrillation (triggered by vagal overactivity)
• Procainamide in Wolff-Parkinson-White syndrome
• Increases QT and QRS interval

Answer 13

Class Ia

Question 14

Medical Uses:

• Treatment and prevention during and immediately after myocardial infarction, though this practice is now discouraged given the increased risk of asystole
• V-Tach

Answer 14

Class Ib

Question 15

Medical Uses:

• Prevents paroxysmal atrial fibrillation
• Treats recurrent tachyarrhythmias of abnormal conduction system
• Contraindicated immediately after myocardial infarction

Answer 15

Class Ic

Question 16

Medical Uses:

• Decrease myocardial infarction mortality
• Prevent recurrence of tachyarrhythmias
• Propranolol has sodium channel-blocking effects

Answer 16

Class II

Question 17

Medical Uses:

• In Wolff-Parkinson-White syndrome
• (Sotalol:) ventricular tachycardias and atri al fibrillation
• (Ibutilide:) atrial flutter and atrial fibrillation
• (Amiodarone): haemodynamically stable ventricular tachycardia[4]

Answer 17

Class III

Question 18

Medical Uses:

• Prevent recurrence of paroxysmal supraventricular Tach
• Reduce ventricular rate in patients with atrial fibrillation

Answer 18

Class IV

Question 19

Medical Uses:
-Used in supraventricular arrhythmias, especially in heart failure with atrial fibrillation, contraindicated in ventricular arrhythmias. or in the case of magnesium sulfate, used in torsades de pointes.

Answer 19

Class V

Question 20

Class that lengthens the action potential (right shift)

Answer 20

Class Ia

Question 21

Class that does not significantly affect the action potential (no shift)

Answer 21

Class Ic

Question 22

Increases refractory period, slows conduction, greater effect on damaged tissue compared to normal tissue. (Incr QRS & Q-T intervals)

Answer 22

Class Ia

Question 23

A-fib, A-flutter, supra ventricular arrythmias and ventricular arrythmias

Answer 23

Class Ia

Question 24

shortens duration of refractory period (Decr Q-T interval)

Answer 24

Class Ib

Question 25

ventricular tachycardia, a-fib

Answer 25

Class Ib

Question 26

slows conduction (Incr QRS interval)

Answer 26

Class Ic

Question 27

atrial and suptraventricular arrythmias

Answer 27

Class Ic

Question 28

slows repolarization and lengthens refractory period; depresses automaticity, decreases AV conduction and decreases HR and contractility (Decr HR; Incr P-R interval)

Answer 28

Class II

Question 29

long term suppression of ventricular arrythmias ; reduces mortality & second cardiovascular events post MI

Answer 29

Class II

Question 30

Increases refractory period (Inc Q-T interval)

Answer 30

Class III

Question 31

ventricular and atrial arrythmias (V-tach & Afib)

Answer 31

Class III

Question 32

Increases refractory period and AV node conduction; SA node is slowed (Decr HR; Incr P-R interval)

Answer 32

Class IV

Question 33

supraventicular tachycardias, and rate reduction of afib/flutter

Answer 33

Class IV

Question 34

AV nodal conduction prolonged, SA node slowed (Drug Specific)

Answer 34

Class V

Question 35

Sodium Potassium ATPase inihibition

Answer 35

Class V