Anti-Allergy Agents (M1)

Question 1

What type of hypersensitivity reaction is taking place in the case of most acute ocular allergies?

Answer 1

type I`

Question 2

What are the three major categories of secreted items from a mast cell during type I hypersensitivity?

Answer 2

1. granule contents
2. membrane phospholipids
3. cytokines

Question 3

What are the granule contents that are released from a mast cell during type I hypersensitivity?

Answer 3

1. histamine
2. proteases
3. chemotactic factors (ECF, NCF)

Question 4

What are the major ocular surface signs and symptoms of type I hypersensitivity?

Answer 4

1. itch
2. redness and conj injection
3. papillary reaction of palpebral conj
4. tearing
5. conj chemosis

Question 5

What is the standard treatment groups for acute allergic conjunctivitis or seasonal flare-ups?

Answer 5

1. topical antihistamine/mast cell stabilizers
2. topical steroids
3. oral antihistamines

Question 6

What is the standard treatment groups for chronic/year round allergic conjunctivitis?

Answer 6

1. topical antihistamine/mast cell stabilizers

2. oral antihistamines