Antenatal Care: Pregnancy Disorders Flashcards

Gestational Diabetes Anaemia

1
Q

Define gestational diabetes

A

impaired glucose tolerance in pregnancy

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2
Q

What is the most common disorder in pregnancy

A

PIH

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3
Q

What is the second most common disorder in pregnancy

A

GDM

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4
Q

What are 6 RF for gestational diabetes

A
Asian 
FH
BMI >30
Previous GDM 
Previous macrocosmic baby 
PCOS
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5
Q

How do the majority of women with gestational diabetes present

A

Asymptomatic

May have polyuria and polydipsia

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6
Q

Explain pathophysiology of gestational diabetes

A

During pregnancy insulin resistance increases. Meaning insulin demand increases by 30%. If an individual has a borderline pancreatic reserve, they will be unable to maintain insulin demand and hence experience transient hyperglycaemia.

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7
Q

Explain foetal consequences of gestational diabetes

A

Glucose crosses the placenta, but insulin does not. This causes foetal hyperglycaemia. Causing foetus to produce more insulin. When foetus is born hyperinsulinaemia, without high maternal glucose, causes hypoglycaemia.

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8
Q

What is the effect of insulin on foetal lungs

A

Decreases pulmonary surfactant production which can lead to transient tachypnoea newborn

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9
Q

What is first-line investigation for GDM

A

OGTT

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10
Q

What is performed with OGTT

A

Fasting glucose

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11
Q

What fasting glucose indicates GDM

A

> 5.6

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12
Q

What OGTT indicates GDM

A

> 7.8

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13
Q

When is OGTT offered if previous GDM

A

16W

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14
Q

When is OGTT offered if asian, FH or BMI >30

A

28W

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15
Q

When is OGTT offered if glycosuria

A

Anytime +2 glucose, offer OGTT

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16
Q

What are the 3 antenatal time periods OGTT offered

A
  1. 16W = previous GDM
  2. 28W = RFs
  3. Anytime glycosuria +2
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17
Q

What is first-line management for GDM

A

Lifestyle advice: try for 2W if fasting blood glucose <7

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18
Q

How often should someone with GDM measure their blood glucose

A

Measure QDS

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19
Q

What is second-line management for GDM

A

Metformin

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20
Q

When is metformin offered

A

If no improvement in blood glucose seen by lifestyle advice alone after 2W

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21
Q

What is third-line for GDM

A

Glibenclamide

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22
Q

When is glibenclamide only offered

A

If individual cannot tolerate metformin

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23
Q

When is insulin started for GDM

A
  1. Beginning if Blood glucose >7

2. Plasma glucose 6-6.9 and evidence foetal complications (macrosomia)

24
Q

Explain scanning in child with GDM

A

Additional scans at 28, 32 and 36W

25
Q

When should delivery be aimed for if on metformin

A

37W

26
Q

When should delivery be aimed for if GDM managed by glucose alone

A

40+6

27
Q

What is fasting blood-glucose target in GDM

A

5.3

28
Q

Explain OGTT

A

Women is given 75g glucose and then blood glucose measured 2h later

29
Q

How long post-delivery should diabetic medication be stopped

A

Immediately

30
Q

What should be checked at 6-13W

A

Blood glucose

31
Q

Explain post-natal screening after GDM

A

Check annually, due to increased risk T2DM

32
Q

Explain further pregnancies following GDM

A

Screen at 16W with OGTT

33
Q

What are two maternal risks of GDM

A

T2DM

Future GDM

34
Q

What are 5 foetal complications of GDM

A
Macrosomia 
Organomegaly 
Polycythaemia 
Pre-maturity 
Polyhydramnios 
Hypoglycaemia 
Respiratory distress syndrome
35
Q

What is the risk with macrosomia

A

Prolonged Labour
Instrumental delivery
Shoulder dystocia

36
Q

What is anaemia

A

Deficiency in haemoglobin

37
Q

What Hb defines anaemia in first trimester

A

<110

38
Q

What Hb defines anaemia in second and third trimester

A

<105

39
Q

What Hb defines anaemia post-natally

A

<100

40
Q

Explain why anaemia is common in pregnancy

A

Increase in plasma volume causing physiological haemodiluation

41
Q

What are 4 risk factors for anaemia in pregnancy

A

Age
Previous IDA in pregnancy
Haemaglobinopathies
Poor diet

42
Q

What are 3 symptoms of anaemia in pregnancy

A

Breathlessness
Dizziness
Fatigue

43
Q

What are 3 signs of anaemia

A

Pale
Kolonychia
Angular stomatitis

44
Q

What is used to diagnose anaemia in pregnancy

A

FBC

45
Q

How will Hb present in anaemia in first trimester

A

<110

46
Q

How will Hb present in anaemia in second trimester

A

<105

47
Q

How will Hb present in anaemia in third trimester

A

<105

48
Q

How will Hb present in anaemia postnatally

A

<100

49
Q

When should all women be screened for anaemia

A

12W and 28W

50
Q

What is first line for anaemia in pregnancy

A

Oral Iron

51
Q

What is second line for anaemia in pregnancy

A

Ferinject (Parental Iron)

52
Q

How does obstetric cholestasis present

A

Pruritus soles and feet = worse at night

Jaundice (20%)

53
Q

How will LFTs present in obstetric cholestasis

A

Raised ALT, AST

54
Q

How is obstetric cholestasis managed

A

Ursodeoxycholic acid

55
Q

If abnormal coagulation profile in obstetric cholestasis what should be given

A
Vitamin K (10mg PO) to mother 
IM vitamin K to foetus on delivery
56
Q

What is main complication of obstetric cholestasis

A

Pre-maturity

57
Q

What is another complication os obstetric cholestasis to the foetus

A

Meconium aspiration