Antenatal Care: Pregnancy Disorders Flashcards
Gestational Diabetes Anaemia
Define gestational diabetes
impaired glucose tolerance in pregnancy
What is the most common disorder in pregnancy
PIH
What is the second most common disorder in pregnancy
GDM
What are 6 RF for gestational diabetes
Asian FH BMI >30 Previous GDM Previous macrocosmic baby PCOS
How do the majority of women with gestational diabetes present
Asymptomatic
May have polyuria and polydipsia
Explain pathophysiology of gestational diabetes
During pregnancy insulin resistance increases. Meaning insulin demand increases by 30%. If an individual has a borderline pancreatic reserve, they will be unable to maintain insulin demand and hence experience transient hyperglycaemia.
Explain foetal consequences of gestational diabetes
Glucose crosses the placenta, but insulin does not. This causes foetal hyperglycaemia. Causing foetus to produce more insulin. When foetus is born hyperinsulinaemia, without high maternal glucose, causes hypoglycaemia.
What is the effect of insulin on foetal lungs
Decreases pulmonary surfactant production which can lead to transient tachypnoea newborn
What is first-line investigation for GDM
OGTT
What is performed with OGTT
Fasting glucose
What fasting glucose indicates GDM
> 5.6
What OGTT indicates GDM
> 7.8
When is OGTT offered if previous GDM
16W
When is OGTT offered if asian, FH or BMI >30
28W
When is OGTT offered if glycosuria
Anytime +2 glucose, offer OGTT
What are the 3 antenatal time periods OGTT offered
- 16W = previous GDM
- 28W = RFs
- Anytime glycosuria +2
What is first-line management for GDM
Lifestyle advice: try for 2W if fasting blood glucose <7
How often should someone with GDM measure their blood glucose
Measure QDS
What is second-line management for GDM
Metformin
When is metformin offered
If no improvement in blood glucose seen by lifestyle advice alone after 2W
What is third-line for GDM
Glibenclamide
When is glibenclamide only offered
If individual cannot tolerate metformin