ANTACIDS-DDIs Flashcards
How do Antacids affect the absorption of amphetamines
,Absorption of amphetamines is increased, and excretion is decreased. Avoid concurrent use or monitor response to therapy.
What happens to the absorption of rosuvastatin when taken with Antacids
,Absorption of rosuvastatin is decreased. Separate doses by at least 2 hours. Infrequent use of antacids is unlikely to cause clinically significant interaction.
How do Antacids interact with enteric-coated medications
,Increased gastric pH may cause premature breakdown of the enteric coating. Separate doses by at least 2 hours.
How do calcium carbonate, magnesium hydroxide, and aluminum hydroxide interact with levothyroxine
,Absorption of levothyroxine is delayed or impaired. Separate doses by at least 4 hours.
What is the effect of calcium carbonate, magnesium hydroxide, and aluminum hydroxide on the absorption of tetracyclines
,Absorption of the antibiotic is decreased. Separate doses by at least 4 hours.
What is the recommended timing for taking antibiotics (e.g., fluoroquinolones) with magnesium hydroxide and aluminum hydroxide antacids
,Take the antibiotic 2 hours before or 6 hours after taking the antacid.
How do magnesium hydroxide and aluminum hydroxide interact with azithromycin
,Absorption of the antibiotic is decreased. Separate doses by at least 2 hours.
What is the potential drug interaction of sodium bicarbonate with quinidine
,Increased urinary pH may decrease renal excretion of quinidine. Avoid concurrent use or monitor response to therapy.
What is the potential drug interaction of sodium bicarbonate with salicylates
,Increased urinary pH may increase renal excretion of salicylates. Avoid concurrent use or monitor for decreased response to salicylates.
How do Antacids, H2RAs, and PPIs interact with Erlotinib, dasatinib, gefitinib, other TKIs, rilpivirine, and ledipasvir/sofosbuvir
,Increased gastric pH decreases the absorption of these medications.
What is the recommended management/preventive measure when taking Erlotinib, dasatinib, gefitinib, other TKIs, rilpivirine, or ledipasvir/sofosbuvir along with Antacids, H2RAs, or PPIs
,Avoid concurrent use of PPI or H2RA; separate the administration from antacids by several hours.
What is the potential drug interaction when taking Antacids with Itraconazole, ketoconazole, iron, or atazanavir
,Increased gastric pH may decrease disintegration, dissolution, or ionization of the drug leading to decreased absorption. Separate doses by at least 2 hours.
