ANS second page

Question 1

Cholinergic Agonists function?

Answer 1

promote the activation of cholinergic transmission by

• activation of cholinergic receptors
• prevent the acetylcholine degradation

Question 2

2 receptors of Cholinergic Agonists

Answer 2

Muscarinic - acts on visceral organs
Nicotinic (neural or neuromuscular)
Neural - found on the post synaptic neuros of both sympathetic and parasymp
Nueromuscular - found on skeletal muscles

Question 3

Cholinergic receptors are _ proteined receptors?

Answer 3

G

Question 4

The effect of cholinergic receptors are mediated by 3 intracellular secondary messenger?

Answer 4

IP3
DAG
CGMP

Question 5

Drugs under Direct Acting Choline Esters?

Answer 5

ABCM
Acetylcholine
Carbachol
Metacholine
Bethanecol

Question 6

Definition of Quarternary Ammonium Group

Answer 6

poorly absorbed in the CNS

Question 7

Explain the degradation of Acetylcholine and the drugs resistant to acetylcholinesterase

Answer 7

Acetylcholine is easily degraded by acetylcholinesterase (short half life)
Methanecol, bethanecol, carbachol = resistant to acetylcholinesterase

Question 8

Drugs under Cholinomimetic Alkaloids

Answer 8

LMNP
Lobeline
Muscarine
Nicotine
Pilocarpine

Question 9

Nicotine effects?

Answer 9

Has more CNS effect than skeletal muscle effect