ANS 3rd page

Question 1

INDIRECT ACTING CHOLINERGIC AGONIST functions

Answer 1

Drugs that act by inhibiting acetylcholinesterase

Question 2

FUNCTION OF EDROPHONIUM

Answer 2

Binds electrostatically reverisble with acetylcholinestrase. Therefore, short duration is observed

Question 3

FUNCTION OF CARBAMATES

Answer 3

Bindds covalently reversible with acetylcholieterase. Therefore, longer duration of action than edrophonium

Question 4

DRUGS UNDER CARBAMATES

Answer 4

Neostigmine
Physostigmine - naturally occurring carbamates
Pyridostigmine
Carbaryl - very lipid solubility

Question 5

DRUGS UNDER ORGANOPHOSPHATES and function

Answer 5

Echotiophate - OLY DRUG USED IN ORGANOPHOSPAHTE
Soman, Sarin, Tabun - nerve gases
Malathion and Parathion -insecticides
Organophoshate - binds irreversibly (covalent) with organopshopahte