ANS fourth page

Question 1

CHOLINERGIC ANTAGONIST

Answer 1

antagonizing the effect of muscarinic and nicotinc receptor

Question 2

Prototype of Muscarinic ANTAGONIST

Answer 2

ATROPINE aka HYSOCAMINE, ATROPA BELLADONA, HYOSYAMUS NIGER

Question 3

mnemonics of side effects of atropine

Answer 3

blind as a bat (mydriasis)
red as a beet (flushing)
dry as bone (Drying of mouth/constipation)
hot as hades (fever/absence of thermoregulatory sweating)
heart races on alone (tachycardia/hypertension)
mad as a hatter (hallucinations/delirium)

Question 4

FUNCTION OF NICOTINIC GANGLIONIC RECEPTORS

Answer 4

rarely used drug clinically because of the unpredictable responses

Question 5

DRUGS USED UNDER NICOTINC GANGLIONIC RECEPTORS

Answer 5

Hypertensive emergency: TRIMETAPHAN
Nicotine cessation: Mecamylamine (can cross BBB)
Other agents (only used as experimentally):
HEXAMETHONIUM - short duration
TRIETHYLMANNONIM - PO