ANS fifth page Flashcards
define the function of NICOTNIC MUSCULAR ANTAGONISTS
inhibit the binding of Nicotinic Muscular Antagonists. highly ionized and do not readily cross the blood brain barrier
Main effect of NICOTINIC MUSCULAR ANTAGONISTS
Paralysis - useful during major surgeries
Depolarizing Blocker function and drug
SUCCINYLCHOLINE
(binds to the NM receptor but promotes depolarization. Longer activation of NM receptor could desensitized which eventually incapable of mediating muscle contraction)
Nondepolarizing Blockers function
antagonizes the Nm receptor to promote paralysis
Nondepolarizing Blocker drugs
-curarine, -curium, -curonium Tubocurarine Atracurium Doxacurium Metocurine Mivacurium Pancuronium Rocuronium Vecoronium
MOST COMMON COMPLAINT OF NICOTNIC MUSCULAR ANTAGONISTS
Muscle pain/mylagia especially with succinylcholine
Succinylcholine when combined with HALOTHANE
Arrythmia