ANS pharm DSA Flashcards
Ach
- major neurotransmitter of the parasympathetic ns
- all preganglionic autonomic fibers
- all postganglionic parasympathetic fibers
- (sweat glands) postganglionic sympathetic fibers
Norepi
- major neurotransmitter of sympathetic ns
- vast majority of postganglionic sympathetic fibers
Dopamine
Norepi and epi precursor
-acts on CNS and renal vascular smooth m.
Ach (cholinergic) receptor types (2)
nAChR (ionotropic)
mAChR (metabotropic)
Which cholinergic and adrenergic receptors use Gq and what is its mechanism of action
m1,3,5
a1
Activates PLC; IP3, DAG cascade
Which cholinergic and adrenergic receptors use Gi and what is its mechanism of action
M2,4
a2
inactivates adenylyl cyclase
What transports NE, Epi, DA and 5-HT into visicles
Vesicular monoamine transporter (VMAT-2)
Which adrenergic receptor is most sensitive to Epi over NE
b2
function of a1 receptors
stimulate contraction of all smooth muscle
vascular - vasoconstriction
decreased secretion of bronchial glands
function of b2 receptors
relax smooth muscle - vasodilation
b2 agonists used as asthma treatment. can relax smooth muscle around bronchioles
function of muscarinic receptors
contract smooth m. (different intracell. signal than a1)
what is the effect of b1 receptors in the heart
increase:
- HR
- contractility
- automaticity
- conduction
what is the effect of M2 receptors in the heart
decrease:
- HR
- contractility
- conduction
what is the effect of M3 receptors in enothelium
activation of NO synthase
what is the effect of b2 receptors in the lungs
tracheal and bronchial smooth m. relaxation
increased secretion of bronchial glands
