ANS - drugs

Question 1

Sympathetic agonists (2)

Answer 1

• sympathomimetics
• catecholamines

*they are alpha or beta agonists

Question 2

sympathetic antagonists

Answer 2

sympatholytics

Question 3

Parasympathetic agonists (2)

Answer 3

• parasympathomimetics

- cholinergics

Question 4

Parasympathetic antagonists (2)

Answer 4

• parasympatholytics

- anticholinergics

Question 5

___ receptors are located in the blood vessels (except in muscles)

Answer 5

Alpha

-cause vasoconstriction

Question 6

___ receptors are located in the myocadrium

Answer 6

B1

-cause increase in HR and contractability

Question 7

___ receptors are located in the vessels of coronary, bronchial muscle
and skeletal muscle

Answer 7

B2

-cause vasodilation and broncho dilation

Question 8

___ receptors are located in the effector

organs

Answer 8

Muscarinic (M)

Question 9

___ receptors are located in the autonomic ganglia, in the adrenal cortex, neuromuscular junction

Answer 9

Nicotinic (N)

Question 10

What are the catecholamine drugs? (4)

Answer 10

1. Adrenaline: activates alpha and beta
2. Noradrenaline: activates alpha and beta 1. No beta2.
3. Dopamine: activates alpha and beta (dose dependent)
4. Isoprenaline: activates beta

Question 11

What are the sympathomimetic drugs categories? (3)

Answer 11

• alpha 1 agonist
• beta 1 agonist
• beta 2 agonist

Question 12

What are the mixed sympathomimetics? (2)

Answer 12

Ephedrine Amphetamine

Question 13

What is the classification and action of Adrenaline?

Answer 13

• Catecholamine

- activates alpha and beta

Question 14

What is the classification and action of Noradrenaline?

Answer 14

• Catecholamine
• activates alpha and beta1

*NO beta2

Question 15

What is the classification and action of dopamine?

Answer 15

• Catecholamine

- activates alpha and beta (dose dependent)

Question 16

What is the classification and action of isoprenaline?

Answer 16

-activates beta

Question 17

Which catecholamine does not activate b2

Answer 17

noradrenaline

Question 18

What are the a1 sympathomimetic drugs?

Answer 18

• mucosal decongestants
  1. Phenylephrine (systemic and topical)

2.Oximetazoline (topical)

Question 19

What is Phenylephrine (3)

Answer 19

• a1 sympathomimetic drug
• musocal decongestant
• systemic and topical

Question 20

What is Oximetazoline (3)

Answer 20

• a1 sympathomimetic drug
• musocal decongestant
• topical

Question 21

What is the b1 sympathomimetic drug?

Answer 21

dobutamine

Question 22

What are the b2 sympathomimetic drugs? and action?

Answer 22

• bronchodilation
  1. Salbutamol
  2. Terbutaline

Question 23

Why are the ‘catecholamines’ named that?

Answer 23

• Adrenaline, noradrenaline and dopamine

- have a common group catechol 3,4-dihydroxyphenyl & ethylamino side chain

Question 24

Which catecholamine is synthetic?

Answer 24

isoprenaline

Question 25

Whats the metabolic pathway for forming adrenaline?

Answer 25

1. L-tyrosine —> L-DOPA (ENZ: Tyrosine hydroxylase)
2. L-DOPA –> Dopamine
   (ENZ:Aromatic amino acid decarboxylase)
3. Dopamine –> Noradrenaline (
   Dopamine β-hydroxylase Phenylethanolamine N-methyltransferase
   Adrenaline