ANS - drugs Flashcards
Sympathetic agonists (2)
- sympathomimetics
- catecholamines
*they are alpha or beta agonists
sympathetic antagonists
sympatholytics
Parasympathetic agonists (2)
- parasympathomimetics
- cholinergics
Parasympathetic antagonists (2)
- parasympatholytics
- anticholinergics
___ receptors are located in the blood vessels (except in muscles)
Alpha
-cause vasoconstriction
___ receptors are located in the myocadrium
B1
-cause increase in HR and contractability
___ receptors are located in the vessels of coronary, bronchial muscle
and skeletal muscle
B2
-cause vasodilation and broncho dilation
___ receptors are located in the effector
organs
Muscarinic (M)
___ receptors are located in the autonomic ganglia, in the adrenal cortex, neuromuscular junction
Nicotinic (N)
What are the catecholamine drugs? (4)
- Adrenaline: activates alpha and beta
- Noradrenaline: activates alpha and beta 1. No beta2.
- Dopamine: activates alpha and beta (dose dependent)
- Isoprenaline: activates beta
What are the sympathomimetic drugs categories? (3)
- alpha 1 agonist
- beta 1 agonist
- beta 2 agonist
What are the mixed sympathomimetics? (2)
Ephedrine Amphetamine
What is the classification and action of Adrenaline?
- Catecholamine
- activates alpha and beta
What is the classification and action of Noradrenaline?
- Catecholamine
- activates alpha and beta1
*NO beta2
What is the classification and action of dopamine?
- Catecholamine
- activates alpha and beta (dose dependent)
What is the classification and action of isoprenaline?
-activates beta
Which catecholamine does not activate b2
noradrenaline
What are the a1 sympathomimetic drugs?
- mucosal decongestants
1. Phenylephrine (systemic and topical)
2.Oximetazoline (topical)
What is Phenylephrine (3)
- a1 sympathomimetic drug
- musocal decongestant
- systemic and topical
What is Oximetazoline (3)
- a1 sympathomimetic drug
- musocal decongestant
- topical
What is the b1 sympathomimetic drug?
dobutamine
What are the b2 sympathomimetic drugs? and action?
- bronchodilation
1. Salbutamol
2. Terbutaline
Why are the ‘catecholamines’ named that?
- Adrenaline, noradrenaline and dopamine
- have a common group catechol 3,4-dihydroxyphenyl & ethylamino side chain
Which catecholamine is synthetic?
isoprenaline
Whats the metabolic pathway for forming adrenaline?
- L-tyrosine —> L-DOPA (ENZ: Tyrosine hydroxylase)
- L-DOPA –> Dopamine
(ENZ:Aromatic amino acid decarboxylase) - Dopamine –> Noradrenaline (
Dopamine β-hydroxylase Phenylethanolamine N-methyltransferase
Adrenaline
