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Asope's Pharmacology > ANS > Flashcards

ANS Flashcards

1
Q

alpha 1

A

q
constriction
mydriasis

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2
Q

alpha 2

A

i
decrease sympathetic
decrease insulin
decreases aqueous humor

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3
Q

B1

A

s

increase HR

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4
Q

B2

A

s
increases aqueous humor
vasodilation

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5
Q

B3

A

s

thermogenesis of smooth muscle

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6
Q

M1

A

q

CNS

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7
Q

M2

A

i

decrease HR

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8
Q

M3

A

q
increases gland secretion
peristalsis
miosis

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9
Q

D1

A

s

relaxes renal vasculature

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10
Q

D2

A

i

NT release

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11
Q

H1

A

q

allergic reactions

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12
Q

H2

A

s

gastric acid secretion

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13
Q

V1

A

q

smooth muscle contraction of vasculature

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14
Q

V2

A

s

H20 permeability in the collecting ducts

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15
Q

two drugs that stop the release of NE from nerve terminal

A

Bretylium

Guanethidine

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16
Q

reuptake inhibitors of NE

A

Cocaine
TCA
Amphetamine

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17
Q

Releasers of NE from pool

A

Amphetamine
Ephedrine
Tyramine

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18
Q

drug that stops the transformation of dopamine into NE

A

Reerpine

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19
Q

Drug that stops tyrosine from turning into DOPA

A

Metyrosine

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20
Q

explain the negative feedback of NE

A

it binds to the alpha 2 receptor on the presynaptic neuron down regulating itself, so when there is a lot of NE in the cleft, then less will be produced. This is how alpha 2 receptors down regulate sympathetic control

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21
Q

how can tyramine ingestion lead to HTN crisis

A

because when you are on an MAOI then tyramine won’t be broken down and this substance displaces NE into the cleft where it stimulate alpha and beta receptors increasing sympathetic activity

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22
Q

cholinomimetic that activates bowl and bladder muscle. Used in post-op ileus

A

Bethanechol

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23
Q

Cholinomimetic that acts just like Ach by causing miosis and relieving ocular pressure in glaucoma

A

Carbachol

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24
Q

cholinomimetic that stimulates M receptors in airway. used to test for asthma

A

Methacholine

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25
Q

potent stimulater of sweet and tears. treats glaucoma and is used for Sjrogren

A

Pilocarpine

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26
Q

drugs that increase Ach in Alzhemiers

A

Donepezil
Galantine
Rivastigmine

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27
Q

increases ACH and diagnosis Myasthenia Gravis

A

Edrophonium

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28
Q

new way to diagnose Myasthenia Gravis

A

AChR Ab (anti-acetylcholine receptor antiboy)

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29
Q

reversal of neuromuscular blockade and doesn’t penetrate the CNS

A

neostigmine

30
Q

fixes atropine overdose

A

Physostigmine

31
Q

Treats myasthneia graves but doesn’t cross CNS

A

Pyridostigmine

32
Q

organophosphate that irreversibly inhibits ACHe

A

parathion

33
Q

antidote to organophosphate

A

atropine and pralidoxime to regenerate the ACHE

34
Q

muscarinic antagonist used in the eye

A

atropine

tropicamide

35
Q

M antagonist used in the CNS for parkinson

A

Benztrpoine (Park my Benz)

36
Q

M antagonist used before surgery to reduce airway secretion

A

Glycoyrrolate

37
Q

Hyoscyamine and Dicyclominee use

A

M antagonist for antispasmodics for IBS

38
Q

M antagonist that treats asthma and COPDS

A

Ipratropium and Tiotropium

39
Q

M antagonist that reduce bladder spasms and urge incontince

A

Oxybutinin
Solifenacin
Tolterodine

40
Q

M antagonist used for motion sickness

A

Scopolamine

41
Q

what can atropine cause in the following humans
elderly?
men?
infants?

A
  1. acute angle glaucoma (mydriasis)
  2. prostatic hyperplasia
  3. hyperthermia
42
Q

Jimsyn Weed (datura) canc cause what

A

mydriasis in gardner due to plant alkaloids

43
Q

B2 agonist for short term asthma

A

albuterol

44
Q

b2 agonist for long term astham

A

Salmetorol

45
Q

b2 agonist used for cardiac stress test

A

dobutamine

46
Q

durga that treats unstable bradycardia, HF and shock and at high concentrations vasoconstrictor

A

dopamine

47
Q

drug to treat anaphylaxis and asthma and open angle glaucoma. alpha effects at high dose

A

epi

48
Q

works on D1 and treats postop HTN and hypertensive crisis. Vasodilator and promotes naturists

A

fenoldopam

49
Q

B1=B2,

A

isoproterenol

50
Q

Alpha 1 agonist that treats postural hypotension

A

Midodrine

51
Q

alpha >aplha2>B1 treats shock and hyptension

A

NE

52
Q

alpha 1> alpha 2 treats hypotension and given to dilate the eyes
nasal deongestant

A

phenylephrine

53
Q

amphetamine treats three thigs

A

ADHD
narcolepsy
obesity

54
Q

why don’t you give a beta blocker if there is cocaine intoxication

A

because alpha 1 can be stimulated and there is extreme HTN

55
Q

alpha 2 agonist that treats HTN urgency, ADHD and Tourette syndrome

A

clonidine

guanfacine

56
Q

alpha 2 agonist that treats HTN in pregnancy

A

alpha-methyldop

57
Q

tx for pheochromocytoma before surgery to prevent HTN crisis

A

Phenoxybenzamine (irreversible)

58
Q

alpha blocker given to people on MAOI who eat tyramine

A

phentolamine

59
Q

alpha 1 blockers that are used for

  • urinary symptoms of BPH
  • PTSD
  • HTN
A

prazosin (PTSD)
terazosin (not in HTN)
doxazosin
tamsulosin

60
Q

alpha 2 blocker used to treat depression

A

mirtazapine

61
Q

B blocker used for glaucoma because it decreases the secretion of aqueous humor

A

timolol

62
Q

decreases the hepatic venous pressure gradient and portal hypertension and treats bleeding from varices

A

nadolol

propranolol

63
Q

side effect of a b blocker that is dylipdemia

A

metoprolol

64
Q

main UDE of B blocker

A

erectile dysfunction

65
Q

b blocker that combines B1 block, B3 stimulation which activates NO synthase in vasculature

A

Nebivolol

66
Q

posion from puffer fish that binds fast sodium channels in the heart and the nerves preventing depolarization

A

tetrodotoxin

67
Q

poison that opens sodium channels causing depolarization and the symptoms resemble cholinergic poisoning

A

Ciguatoxin (reef fish, snapper and moray eel)

68
Q

a poison that converts bacterial histidine into histamine and is commonly misdiagnosed as fish poisoning

A

Spoiled dark meet fish (tuna, mahi mani or bonito)

“Scromboid Poisoning”

69
Q

antidote to acetaminophen

A

n-acetylcystein

70
Q

amphetamine antidote

A

NH4CL (acidify urine)

Asope's Pharmacology (7 decks)

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