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Microbiology > Anitvirals > Flashcards

Anitvirals Flashcards

1
Q

(Val)Acyclovir

A

nucleoSide analogue → polymerase

HSV, VZV

Val=PO / Acyc=PO,IV,topical

well tolerated, rare renal and neurologic

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2
Q

Famciclovir

A

nucleoSide analogue → polymerase

HSV, VZV

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3
Q

Penciclovir

A

nucleoSide analogue → polymerase

HSV

topical?

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4
Q

Trifluorothymidine

A

nucleoSide analogue → polymerase

HSV

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5
Q

(Val)Ganciclovir

A

nucleoSide analogue → polymerase

CMV

Val=PO / Gan=PO,IV,intraocular

myelosuppresion, headache, fever, rash

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6
Q

Cidofovir

A

nucleoTide analogue → polymerase

CMV

IV

nephrotoxic, GI, neutropenia

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7
Q

Foscarnet

A

pyrophosphate analogue → polymerase

HSV, CMV

IV

dirently nephrotoxic, penile ulcers

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8
Q

Fomivirsen

A

anti-sense RNA → translation

CMV-retinitis

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9
Q

Amantadine

A

ion channel blocker (HA) → uncoating

Influenza A

PO

reversibly neurotoxic, nausea, dry mouth

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10
Q

Rimantadine

A

ion channel blocker (HA) → uncoating

Influenza A

PO

reversibly neurotoxic (less common), nausea, dry mouth

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11
Q

Oseltamivir

A

sialic acid analogue (NA) → virus release

Influenza A and B

PO

nausea, vomiting

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12
Q

Zanamivir

A

sialic acid analogue (NA) → virus release

Influenza A and B

inhalation

bronchospasm, nasuea, vomiting, diarrhea

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13
Q

Ribavirin

A

nucleoside analogue → viral mRNA

RSV, HCV, Lassa

PO,IV,inhalation

hemolytic anemia, headache, rash, highly teratogenic

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14
Q

Palivizumab

A

monoclonoal antibody → virus entry

RSV

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15
Q

Interferon-α

A

immunomodulator → host factors

HCV, HBV?, HPV

SC

flu-like symptoms, depression, myelosuppresion, rash, alopecia, retinopathy

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16
Q

Imiquimod

A

cytokine inducer → host factors

HPV

17
Q

Telaprevir

A

1st gen NS3/4A protease inhibitor → protease

HCV

PO

pruritis, rash is common (FDA black box warning)

18
Q

Boceprevir

A

1st gen NS3/4A protease inhibitor → protease

HCV

PO

anemia, fatigue, dysgeusia, nausea, headache, multiple drug interactions

19
Q

Sofosbuvir

A

2nd gen NS5B inhibitor → polymerase

HCV

PO

well tolerated

20
Q

Simeprevir

A

2nd gen NS3/4A protease inhibitor → protease

HCV (persitent HBV)

PO

well tolerated, photosensitivity, rash, elevated bilirubin

21
Q

Lamivudine

A

nucleoSide analogue → polymerase

HBV, HIV

22
Q

Emtricitabine

A

nucleoSide analogue → polymerase

HBV, HIV

23
Q

Tenofovir

A

nucleoTide analogue → polymerase

HBV, HIV

24
Q

Adefovir

A

nucleoTide analogue → polymerase

HBV

25
Q

Entecavir

A

nucleoSide analogue → polymerase

HBV

26
Q

Telbivudine

A

nucleoSide analogue → polymerase

HBV

Microbiology (4 decks)

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