Angiotensin Antagonists

Question 1

What does angiotensin antagonists antagonize?

Answer 1

RAAS

Question 2

What inhibits angiotensinogen to angiotensin 1

Answer 2

Renin Inhibitor ALISKIREN

Question 3

What inhibits angiotensin 1 to angiotensin 2?

Answer 3

ACEIs (-pril)

Question 4

All ACEIs are prodrugs except

Answer 4

Captopril
Lisinopril
Enalaprilat

Question 5

What is the active metabolic of enalapril

Answer 5

Enalaprilat

Question 6

Orally administered ACEIs undergo?

Answer 6

First-pass activation

Question 7

Captopril is administered _____________ because

Answer 7

2-3 times a day
Short duration

Question 8

It’s absorption is reduced by 30-40% by food

Answer 8

Captopril

Question 9

What weakens liver enzymes

Answer 9

Grape fruit juice

Question 10

What enzyme inhibitor increases the bioavailability of ACEI

Answer 10

Grape fruit juice

Question 11

What does aldosterone increase

Answer 11

Sodium and water reabsorption

Question 12

What does aldosterone decrease

Answer 12

Potassium

Question 13

A partial agonist of AG 2 receptors

Answer 13

Saralasin

Question 14

Adverse effects of ARBs

Answer 14

Hyperkalemia
Neutropenia
Fetal sand neonatal injury and death

Question 15

Adverse effects of ACEIs

Answer 15

Dry cough
Angioedema
Dysgeusia
Hyperkalemia
Fetal and neonatal injury and death

Question 16

Most common side effects of ACEIs

Answer 16

Dry cough

Question 17

What is dysgeusia

Answer 17

Loss of taste

Question 18

ACEIs and ARBs are effective and well tolerated that is preferred for the

Answer 18

Initial treatment of HTN

Question 19

What does ACEIs and ARBs reduce

Answer 19

Risk of stroke and MI

Question 20

ACEIs and ARBs lower BP by

Answer 20

Reducing vascular resistance

Question 21

It reduces the risk of cardiovascular consequences of HTN

Answer 21

ARBs