Angiotensin Antagonists Flashcards
What does angiotensin antagonists antagonize?
RAAS
What inhibits angiotensinogen to angiotensin 1
Renin Inhibitor ALISKIREN
What inhibits angiotensin 1 to angiotensin 2?
ACEIs (-pril)
All ACEIs are prodrugs except
Captopril
Lisinopril
Enalaprilat
What is the active metabolic of enalapril
Enalaprilat
Orally administered ACEIs undergo?
First-pass activation
Captopril is administered _____________ because
2-3 times a day
Short duration
It’s absorption is reduced by 30-40% by food
Captopril
What weakens liver enzymes
Grape fruit juice
What enzyme inhibitor increases the bioavailability of ACEI
Grape fruit juice
What does aldosterone increase
Sodium and water reabsorption
What does aldosterone decrease
Potassium
A partial agonist of AG 2 receptors
Saralasin
Adverse effects of ARBs
Hyperkalemia
Neutropenia
Fetal sand neonatal injury and death
Adverse effects of ACEIs
Dry cough
Angioedema
Dysgeusia
Hyperkalemia
Fetal and neonatal injury and death
Most common side effects of ACEIs
Dry cough
What is dysgeusia
Loss of taste
ACEIs and ARBs are effective and well tolerated that is preferred for the
Initial treatment of HTN
What does ACEIs and ARBs reduce
Risk of stroke and MI
ACEIs and ARBs lower BP by
Reducing vascular resistance
It reduces the risk of cardiovascular consequences of HTN
ARBs
