ANESTHETICS

Question 1

ANESTHETICS: which 2 drugs

Answer 1

Lidocaine

Propofol

Question 2

ANESTHETICS INDICATION

Answer 2

pain-controlled analgesia (PCA)

Question 3

ANESTHETICS ROA

Answer 3

General: IV, inhalation
Regional: *intrathecal, *epidural, infiltration anesthesia, peripheral nerve block, IV, regional block Local: injection, topical

Question 4

ANESTHETICS MOA

Answer 4

reversibly bind a receptor site within the pore of the Na+channels in nerves -> block ion movement through the pore -> blocks action potential for nerve conduction, especially at small myelinated axons that carry nociceptive input

Question 5

ANESTHETICS AE

Answer 5

rare but possible, especially if drug enters systemic circulation: CNS stimulations (tremors, confusion, seizures) progressing to CNS depression.

CV: arrhythmia, bradycardia, hypotension, cardiac arrest. Respiratory depression

Question 6

ANESTHETICS PT SPECIFIC CONSIDERATIONS

Answer 6

Neuromuscular weakness (prolonged drowsiness, potential fall risk, mobilizing patient may positively reduce muscle relaxant drugs). Impaired airway clearance (depress mucociliary clearance, encourage patient to cough and deep breathe -spirometer, expel anesthetic gases and pooled secretions, postural drainage)

Question 7

ANESTHETICS PK/PD CONSIDERATIONS

Answer 7

Can suppress T- B-cell function up to 1 month post-op, older adults - pulm complications increase, reduced cough reflex -> increased risk for pneumonia and post-op atelectasis