Anemia Quiz Row 3 and 4

Question 1

Sickle Cell Disease

-Causes

Answer 1

• Inherited amino acid substitution

- B6(A3) Glu –> Val

Question 2

Sickle Cell Disease

-MCV, MCHC, RDW

Answer 2

• MCV = normal
• MCHC = normal
• RDW = increased

Question 3

Sickle Cell Disease

-Morphology

Answer 3

• sickle cells
• target cells
• NRBCs

Question 4

Sickle Cell Disease

-Diagnostic Tests

Answer 4

-Solubility test = positive
-electrophoresis = 85-100% Hb S
< 15% Hb F

Question 5

B - Thalassemia Major

-Causes

Answer 5

-Inherited deficiency of B-globin chain production

Question 6

B - Thalassemia Major

-MCV, MCHC, RDW

Answer 6

• MCV = decreased
• MCHC = decreased
• RDW = increased

Question 7

B - Thalassemia Major

- Morphology

Answer 7

• microcytes
• basophilic stippling
• NRBCs

Question 8

B - Thalassemia Major

-Diagnostic Tests

Answer 8

-electrophoresis = 0-30% Hb A1

60-95% Hb F