Anemia + Asthma + CVD + MSK + Joint Flashcards
Correct definition about anemia is:
- decrease in O2 carrying capacity
- decrease in RBC
- decrease in getting rid CO2
Most common cause of anemia
IDA
How do drugs, acohol, and tobacco cause anemia?
Affect Stomach lining causing nutritional anemia
What cardiovascular complication is seen with anemia?
Ejection systolic murmur\ S3 gallop
What are the most important labs in anemia
CBC and smear
Best lab tool in IDA is:
Ferritin
Name high MCV + Normal RDW
- folic & B12
- Hypothyroidism
- Drug-induced anticonvulsants.
- MDS
- BM failure
Name low MCV + high RDW
- active hemolysis with brisk reticulocytosis
Name Normal MCV + Normal RDW
- Chronic disease
- Hemorrhage
- Inflammation (acute)
- Malignancy
- Transient erytheroblastopenia childhood.
Name Normal MCV + high RDW
- Hemolytic anemia (sickle cell\ G6pd\ membrane\ microangiopathies like DIC & HUS\ immune)
Name low MCV + Normal RDW
- Sideroblastic anemia
- Lead poisoning
- IDA
- Thalassemia trait
- Chronic disease
Name low MCV + high RDW
- Thalassemia (HBS-SB)
- HBC & HBE.
What will you order if you see low Hg and MCV
Lead level - Iron profile - Electrophoresis.
What will you order if you see low Hg and normal MCV
- electrophersis
- Coomb
- Osmotic fragility
- enzyme assays
- other diseases.
What will you order if you see low Hg and high MCV
- B12\folic\thyroid screen
- BM aspiration
- hemolysis
Normal MCV values is
80-100
Low:
- MCV
- Iron
- Ferritin
- TIBC
Is:
Anemia of chronic diseases
Low: - MCV - Iron - Ferritin High - TIBC
Is:
IDA
Low: - MCV High - Iron - Ferritin
Is:
Thalassemia
What is the role of mentezer index?
Identify thalassemia:
- MCV\RBC < 13
- Iron levels >30
Less than (13, 12,11) is mild anemia in …. & … & …..
1- male
2- nonpregnant women
3- pregnant women..
Is ferritin always right to diagnose IDA?
No because it might increase in some cases in reactions
Even if increased, check for TIBC and iron
Common risk factors for IDA
- increased intrauterine bleeding
- celiac
- NSAID
- Hpylori or peptic ulcer
When should we suspect malignancy in IDA?
- men
- post menapausal
- RF
- elderly
Iron therapy is:
120 elemental iron for 3m
How to take iron supplements
Empty stomach, No PPI or calcium, vit D
Falsly elevated A1c is due to:
IDA
AAP recommends screening for IDA at
1 year
UPSTSF VS AAFP\CDC for pregnancy screening of IDA is:
USPSTF: not sufficent data
But rest recommend it
What happens with
1- 2 - 3 - and 4 deletions of Hemoglobin A
1: nothing
2: nothing except in pregnancy\illness
3: HBH “splenomegaly & avoid oxidative”
4: hydrops fetalis “not surviving”
What is the major drug that should be avoided in G6pd?
Nitrofuritoin for UTI > cause hemolysis
If b12 is boarderline low, order:
Homocystine +methylmalonoic
Risk factors for future episodes of asthma attacks.
- pregnancy
- use ICS, oral steroid, high use of inhaler
- comorbidities - psychological
- exposure to allergens - eosinphilia
- low FEV1 - ICU admission
Most common ICS medication
Budsonide
Fluticasone
Ciclosonide
Most common reliever combination therapy is:
- Sertride: salmeterol + fluticasone
- Simbicort: Formeterol + Budsonide
Explain the initiation process of asthma treatment:
1: >20 no RF
2: >20 yes RF - 16 to 19
3: <16
4: <16 severe go for referral.
Explain the maintainace process of asthma treatment
- Maintain: >20 for 3 months.
- Step up: <19
How is step 3 different in child <5 than adults?
instead of laba+ICS we double dose the ICS
“Due to fear of bronchospam)
When to step down asthma treatment?
When pts is controlled after 3 months and we can find a minimum therapy to maintain good control
What do you recommend patients with adverse effect of medications?
- change medics or decrease dose\frequency
- anti-fungal therapy for severe thrush
- wash mouth after use
- use spacer
How to evaluate moderate asthma acute attack
Full sentence, agitated alert, may\not use accessory.
- RR:20-30
- HR:<120
- SaO2: >92
- PEFR: 50-70%
How to treat moderate asthma?
1- O2 to keep saturation 2- nebulization or MDI of salbutamol 3- oral prednisone STAT 4- discharge & Start on step 3 5- close follow up
How to treat severe and life-threatning asthma
1- O2 2- Salbutamol nebulizer 3- oral prednisone or 100-200 IV hydrocortisone 4- ipratropium 5- referral
Pediatric assessment score for acute asthma attack
- scalene muscle contraction
- suprasternal retraction
- air entry
- O2 sat.
A child with acute asthma attack and pram 1-3, how to manage
1- O2
2- Salbutamol Q20 for 2 doses
3- ipratropium or oral steroid
4- reassess
What test is used to confirm bronchial asthma?
Spirometery with reversibility test
A patient with known asthma present with acute presentation, what could be the cause other than asthma?
- Viral infection
- pnemonia
- smoke
- exercise
- rhinosinusitis
- GERD
- Obesity
- B-blocker, asprin & NSAID usage.
- sleep disorders
What are the findings in asthma examination
- bilateral expiratory wheez
- high pitch
Reversibility improvement in spriometery with bronchodilator is:
FEV1 (12%) + 200ml
When to preform spiromentery in children?
At 6 years
How to diagnose child with asthma?
More than 3 attacks of SOB or Wheeze in one season with more than 2 weeks of cough
How to diagnose child below 6 years with asthma
Wheeze of >3 episodes \+ (1 major) Atopy , Family hx, skin test \+ (2 minor) Eosinophilia, food allergy
How much is the recommended physical activity?
- 150\w of moderate
- 75\w of vigorous
When do we start screening men for dyslipidemia?
- No risk: 35
- Risk: 20
When do women start screening men for dyslipidemia?
- No risk: 45
- Risk: 20
When are men and women are at similar risk for dyslipidemia?
- post\early menapause
- premature ovarian failure
What are the secondary causes of dyslipidemia?
- Diet: anorexia - high fat diet
- Medications: Steroid - diuretics - amiodarone.
- Medical conditions: hypothyroidism - pregnancy - nephrotic syndrome
Name high intensity statin agents:
and how much it decreases?
- Atorvastatin 40-50
- Rosuvstatin 20-40
(50%)
Name moderate intensity statin agents:
- Atorva 10-20
- Rosuva 5-10
- Simva 20-40
30-49%
Name low intensity statin agents:
Simvastatin 10mg
When to start patients aged 0-19 on statin?
When they have hypercholestermia in the family
When to start patients aged 20-39 on statin
- family history
- premature ASCVD
- LDL >160
Normal population to start statin:
Above 40
What is the cut-off point for diabetes starting high intensity statin?
20% or LDL >190
When to consider CAC?
Between 5-<7.5
Anything from 1 and above favors statin
If >100 initiate immidiatly
What are the risk enhancers for ASCVD risk score:
- family history of premature
- LDL >160
- women condition
- metabolic syndrome
- ethnicity
- inflammatory disease
- kidney diseases
- elevated CRP- LpA-ApoB
- nephorpathy, retinopathy, neuropathy.
How to differentiate myalgia, myositis, rhabdomyolysis in statin therapy?
- Myalgia: Normal CK
- Rhabdomylsis: CK<10x ULN
- Myositis: more than ULN
In which group of population do you expect to see myalgia?
Young - female - thin - athletes - alcohol - drugs on liver metabolism
Statin works primary on:
Liver - kidney
Liver
When to stop statin therapy?
- If ALT\AST is elevated 3x ULN
- Before 3m of conception & in breast-feeding.
After statin therapy [initiation], when to repeat lipid profile test?
And for [maintenance]
- After 1m - 3m.
- After 3-12m
Statin intolerance is common in:
- Old
- Female
- Hypothyroidism
- Alcoholic
- Hemorrhagic stroke
What are the baseline laboratory investigations for statin therapy?
[TSH - BHCG - Liver\renal function - CK - Hb1c - vitamin D]
Do you stop statins if the GFR is below <30?
You only stop rousvastatin, but the rest decrease their doses.
What are the side effects of gum and lozange in smoking cessation therapy?
Hiccups and dyspepsia (avoid food\drinks)
When to initiate aspirin therapy?
Age 40-70 with no previous risk of bleeding and ASCVD of >20%
Most important risk enhancers for ASCVD are:
- LDL>160
- Family Hx of premature ASCVD
What is your next step when you see your patient with BP >160\100
Look for target oran damage.
When can you immediately diagnose patients w\HTN without any further testing?
- Hypertensive emergency
- Asymptomatic severe HTN >180\120
- target organ damage.
Differences between left and right arm in BP measurement is due to:
Subclavian stenosis (PVD)
Postural hypotension measurment should be in:
1- elderly >65
2- DM
3- dizziness
Hypertension in African American is:
- earlier
- Severer
- commoner
Elevated systolic BP is usually attributed to which cause?
Age
Major categories of OTC medications to be avoided in HTN?
- NSAIDs
- OCP
- Antacids
- Decongestants
- Corticosteroids
- antidepressants & atypical antipsychotics
A patient presents with [HTN + Hypokalemia + Metabolic alkalosis]
Is suspected to have:
Primary aldosteronism
Endocrine disorders that may cause secondary HTN are
- Hyper & hypothyroidism
- Hyperparathyroidism
- Cushing
- Pheochromocytoma
- primary aldosteronism
When to screen for HTN annually and when to screen semi-annually?
- annually: anyone above 18
- Semiannually: anyone with risk factor (prehypertensive - obese)
Typical findings in HTN fundoscopy examinations?
- Cotton wool spots
- arteriolar narrowing\nicking
- hemorrhage
- papillodema.
Initial tests in newly diagnosed HTN:
- electrolyte & creatinine
- urinalysis
- glucose
- TSH
- lipid
- ECG + ASCVD.
Who should you start antihypertensive medications with
1- stage I: w\ [ASCVD 10% - DM - Kidney - 65 - CVD]
2- stage 2: any patient.
Drug of choice for black patient with HTN?
Thiazide or CCB
Drug of choice in renal impairment w\HTN:
ACE or ARB
Drug of choice in HF w\HTN:
B-blocker
Compelling indications for HTN in
- Angina
- Afib\flutter
- CKD
- B-blocker\CCB
- B-blocker\CCB “non-hydro”
- ACE\ARB
Favorable indications for HTN in
- BPH
- tremor\Hyperthyroidism
- Migrane
- osteoprosis
- raynoids
- Alpha blocker
- B-blocker
- B-blocker
- Thiazide
- CCB
antihypertensive Medications that are contraindicated in
- Bronchospastic disease:
- B-blocker
antihypertensive Medications that are contraindicated in
- Liver disease:
Methyldopa
antihypertensive Medications that are contraindicated in
- pregnancy:
ARBs or ACE
antihypertensive Medications that are contraindicated in
- Heart block
B-blocker
antihypertensive Medications that are contraindicated in
- Gout:
Thiazide diuretics
antihypertensive Medications that are contraindicated in
- Hyperkalemia
Aldosterone antagonist
antihypertensive Medications that are contraindicated in
- Hyponatermia
Thiazide
antihypertensive Medications that are contraindicated in
- renovascular disease
ACE and arb
Most common combination therapy is:
ACE\ARB + CCB
In which group of patients would you IMMEDIATELY start combination therapy?
+20 Systolic+10 diastolic of their goal BP.
When do you switch amoldipine (Dihydropyridine) to verapmil\diltizam (non-Dihydropyridine)
Leg swelling
What is drug resistant HTN?
[3 HTN medics] one of them is Diuretic.
Function of the rotator cuff:
SITS
Supra: Abduction
Infraspinatus: external rotation
Teres minor: External rotation
Subscapularis: internal rotation.
Posterior vs anterior shoulder dislocation:
Posterior: inability to external rotation
Anterior: inability to internal rotation
Scapular winging is due to
Serratus anterior muscle injury + Thoracic nerve.
Throwing atheletes are common to develop:
Labrum injury (cluncking shoulder in above head motion)
The test for all ranges of motion
Apley scratch test
Rotator cuff tests are:
- Resisted external rotation
- Drop arm
- empty can test
Impingement tests are:
Hawkins & neer
Explain Hawkin’s - Neer test:
- Flexion -flexion - internal rotation
- internal rotation - flexion
How to test for biceps tendinitis:
- Speed’s: Resist shoulder flexion after 30
- yargson’s: flexion + Resist pronation.
To test for anterior shoulder laxity:
Apprehension test
Sulcus sign indicate:
And is caused usually by which action?
Inferior shoulder instability.
Holding heavy object
- Overuse of shoulder
- worse w\overhead
- Night time pain
this is typical presentation of:
This is treated by:
- Impingement
- conservative > corticosteroid injection > surgery (MRI)
- old patient
- Fall in overstretched hand (trauma)
- Pain in lateral shoulder
- weakness w\external rotation
this is typical presentation of:
This is treated by:
Rotator cuff tear
- Surgery (unless not candidates)> rehab.
- Old + DM
- Acute shoulder pain + no trauma
- decrease in ROM (active\passive)
this is typical presentation of:
This is treated by:
Adhesive capsulitis
- conservative (2y)> surgery
- Young - Fall on his shoulder
- Can’t Abduct\Flex arm
- Palpable coracoid process
- Maintain arm on external rotation
this is typical presentation of:
This is treated by:
Anterior shoulder dislocation
- Surgery if prone to recur (Athletes\military)\No surgery if not prone
- Numbness in first 3 fingers
- worse w\working
this is typical presentation of:
This is treated by:
Carpal tunnel
- splinting\corticosteroid\physio\yoga \theraputic US > surgery if indicated.
- pain in dorsal of radial wrist
- Painful ulnar deviation
- worse w\working
this is typical presentation of:
This is treated by:
Dequiverian tensinovitis
- Ice\Analgesic\Spica splinting > corticosteroid injection
- catching of thumb
- can flex thumb
- palpable nodule in MCP joint
this is typical presentation of:
This is treated by:
Trigger finger
- NSAID\injection at flexor tendon sheath > surgery.
- Unilateral
- worse w\moving
- stiffness <30min
- old\obese
- effusion
- pain in knee joint in medial side
- crepitus\buckling
this is typical presentation of:
Osteoarthritis
- back pain after heavy lifting
- no neurological deficit
this is typical presentation of:
MSK back pain
Fall on outstretched arm usually causes which type of shoulder dislocation?
Posterior shoulder dislocation
The core component for shoulder instability physiotherapy
Rotator cuff strengthening + scapular stabilization
Best 2 tests to confirm Carpal tunnel?
1st: flick sign> pain relief w\shaking wrist
2nd: carpal compression
In which patient will you only diagnose carpal tunnel clinically and not preform any further testing or surgical recommendation?
- pain is mild
- pain is associated w\pregnancy
Which muscles are affected in dequevarian tenosynovitis?
- Abd pollices longus
- Extensory pollices brevis
Spica splinting VS nocturnal splinting indications in MSK injuries:
- Spica: Dequervian tenosynovitis
- Nocturnal: Carpal tunnel
Name associated clinical findings of osteoarthritis in the knees:
Baker’s cyst + Varus\vulgus
Name associated clinical findings of osteoarthritis in the hands:
Heberden\Bouchard
Name associated clinical findings of osteoarthritis in the shoulder and hips:
- shoulder: external rotation limitation
- Hip: internal rotation limitation
What are the radiographic findings in osteoarthritis?
Joint narrowing - subchondral sclerosis - osteophytes
An important advise you need to give your patients with acute low back due to MSK is to:
Continue with life activity.
Oligoarthrtis is defined as
2-4
Most common site for gout
1st metatarso - ankle
If patient has joint pain\swelling and is known for IV drug abuse, you might suspect?
Septic arthritis by staph.
Patient on diuretic is at high risk of developing attacks followed by resolution.
Gout
In any patient with 1 joint effusion, next step is to:
Arthrocentesis
In any patient with joint pain and trauma, next step is to:
X-ray
WBC in gout - osteoarthritis - septic arthritis:
- > 2000
- 200-2000
- > 50,000
Synovial fluid in gout vs psudogout:
- gout: monosodium ureate crystal (needle shaped -ve bifergnce) + poly neutrophils
- psudogout: calcium pyrophosphate & +ve, biferengent, rhomboid
In septic arthritis, synovial fluid analysis should include:
Gram stain
Gout is more common in
M/f
Male
Characterstics of gout
- tophi
- increased ureate levels (not always and no necessary in acute attacks)
- pain and eryhtema and joint space narrowing
Role of plasma ureate
Increase likelihood of gout
What is first line treatment for gout
NSAID
Prophylaxis of gout is
Allopuranol
What are the indications of prophylaxis in gout?
- tophi
- joint destruction
- nephorlithasis
- recurrent 2-3/y
- patient preference
Old man with minor (injury) develops joint swelling/pain/low grade fever reduced
Is likely to be:
Psudogout
The most common causes for acute monoarthritis in elderly is:
Psudogout
First line treatment in psudogout?
Intra-articular steroid injection
Septic arthritis is due to
(Trauma - no trauma)
(Associated w/disease - not associated)
(Most prominent symptom is)
- No trauma
- associated
- decrease ROM
Diff between psudogout and septic arthritis
- septic could be associated with fever.
- psudo: associated with trauma
Spetic arthritis is usually due to
Gram (positive - negative) cocci
Positive
Treatment of choice for septic arthritis is
AB emperic before results of culture
What are the risk factors for septic arthritis?
- old
- immunosuppressed
- OA/RA
- infection spread (hematogeous - contagous)
- prosthesis
- low socioeconmic
- ticks
Gout is more common in
M/f
Male
Characterstics of gout
- tophi
- increased ureate levels (not always and no necessary in acute attacks)
- pain and eryhtema and joint space narrowing
Role of plasma ureate
Increase likelihood of gout
What is first line treatment for gout
NSAID
Prophylaxis of gout is
Allopuranol
What are the indications of prophylaxis in gout?
- tophi
- joint destruction
- nephorlithasis
- recurrent 2-3/y
- patient preference
Old man with minor (injury) develops joint swelling/pain/low grade fever reduced
Is likely to be:
Psudogout
The most common causes for acute monoarthritis in elderly is:
Psudogout
First line treatment in psudogout?
Intra-articular steroid injection
Septic arthritis is due to
(Trauma - no trauma)
(Associated w/disease - not associated)
(Most prominent symptom is)
- No trauma
- associated
- decrease ROM
Diff between psudogout and septic arthritis
- septic could be associated with fever.
- psudo: associated with trauma
Spetic arthritis is usually due to
Gram (positive - negative) cocci
Positive
Treatment of choice for septic arthritis is
AB emperic before results of culture
What are the risk factors for septic arthritis?
- old
- immunosuppressed
- OA/RA
- infection spread (hematogeous - contagous)
- prosthesis
- low socioeconmic
- ticks
Your ddx for a monoarthrtitis would be
- hemorthrosis
- septic arthritis
- gout\psudogout
- osteoarthritis
In patient with history of warfarin, and acute non-traumatic injury and a very swollen\warm knee is most likely to have
Hemathrosis
Name examples of symmetrical and non-symmetrical polyarthritis:
- Symmetrical: RA\SLE
- Non: OA\ psoriatic arthritis
What kind of joints is usually affected in SLE (small - medium - large)?
Small to medium
Name inflammatory diseases that are assocaited with oligoarthritis:
Psoriatic
Ankylosing
What are the systemic features of RA?
- Uveitis
- pneumonitis
- nodules
- fever
differentiate between RA and OA affecting Interphalangeal joints
RA: PIP
OA: DIP
What are the systemic features of SLE?
- malar rash
- oral ulcer
- pleurisy
What are the systemic features of AS?
- uveitis
- pneumonitis
Lab test for RA:
- Specific: Anti-ccp
- RF
Lab test for vasculitis:
- ESR >50
- ANCA
- Biposy
Lab tests for SLE:
- specific: Antismith
- C3\C4
- Anti- DsDNA
Lab test for AS:
HLA B27
Sacroilitis can present in which inflammatory joint diseases?
- psoriatic arthritis
- Ankylosing spondylitis
An important role in family medicine when dealing with RA diagnosis:
Is to diagnose early and treat early to avoid irreversible damage
To manage patients with RA:
1- NSAID & steroid injection or oral
2- refer to rhumatology to presrcribe DMARDs “methotrexate”
Polymylagia rhumatica affect which joint?
Hip and shoulder girdles
Criteria for AS diagnosis:
Back pain in 20 +
- morning stiffness relieved by exercise
- alternating buttock pain
- pain relieved by NSAID
- waking at night due to pain
- extrarticular: enthisitis\ uveitis\ fatigue
Patient with Ankylosing spondylitis have
Kyphosis - lordosis
Kyphosis & decreased flexion
In psoriatic arthritis
which is usually first (psoriasis or arthritis)?
Usually psoriasis but can be either way